Studies on 99mtc-pertechnetate from the MEK solvent extraction generator

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dc.contributor.authorMohammad, Ren_AU
dc.contributor.authorMoore, DEen_AU
dc.contributor.authorMaddalena, DJen_AU
dc.contributor.authorBoyd, REen_AU
dc.date.accessioned2007-11-22T04:17:56Zen_AU
dc.date.accessioned2010-04-30T04:29:31Zen_AU
dc.date.available2007-11-22T04:17:56Zen_AU
dc.date.available2010-04-30T04:29:31Zen_AU
dc.date.issued1984-12en_AU
dc.description.abstractAnalysis by gas chromatography-mass spectrometry and high performance liquid chromatography has revealed organic residues in (99m)Tc-pertechnetate obtained from 99Mo-molybdate by extraction using the organic solvent methylethylketone (MEK). The organic residues have been identified as either (i) low molecular weight carbonyl compounds such as formaldehyde acetaldehyde and acetone presumably caused by the effects of gamma-radiation on MEK or (ii) condensation products resulting from the action of strong alkali on MEK during the extraction process. The quantities of organic residues varied from batch to batch of extracted pertechnetate; up to 40 μg mL -1 was found. When these compounds were tested in rats by addition to a pyrophosphate bone-seeking radiopharmaceutical the tissue distribution was not significantly different from that in the control which contained no added compound. Assay for 99Tc in MEK-derived pertechnetate indicated up to 10 μg mL -1 of 99Tc carrier. An assessment of the biological effect of 99Tc carrier was obtained by (i) red blood cell labelling where 6 ng mL -1 of 99Tc was sufficient to reduce labelling efficiency; and (ii) pyrophosphate tissue distribution where a significant effect was obtained in the presence of 10 μg mL -1 of 99Tc carrier.en_AU
dc.identifier.citationMohammad, R., Moore, D. E., Maddalena, D. J., & Boyd, R. E. (1984). Studies on 99mtc-pertechnetate from the MEK solvent extraction generator. (AAEC/E589). Lucas Heights, N.S.W.: Australian Atomic Energy Commission, Research Establishment.en_AU
dc.identifier.govdoc166en_AU
dc.identifier.isbn0642597995en_AU
dc.identifier.otherAAEC-E-589en_AU
dc.identifier.placeofpublicationLucas Heights, New South Walesen_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/263en_AU
dc.language.isoen_auen_AU
dc.publisherAustralian Atomic Energy Commissionen_AU
dc.subjectSolvent extractionen_AU
dc.subjectHigh-performance liquid chromatographyen_AU
dc.subjectGamma radiationen_AU
dc.subjectBlood cellsen_AU
dc.subjectResiduesen_AU
dc.subjectCarbonylsen_AU
dc.titleStudies on 99mtc-pertechnetate from the MEK solvent extraction generatoren_AU
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