[166Dy]dysprosium/[166Ho]holmium in vivo generator

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dc.contributor.authorSmith, SVen_AU
dc.contributor.authorDi Bartolo, Nen_AU
dc.contributor.authorMirzadeh, Sen_AU
dc.contributor.authorLambrecht, RMen_AU
dc.contributor.authorKnapp, FFen_AU
dc.contributor.authorHetherington, ELen_AU
dc.date.accessioned2025-08-08T04:27:07Zen_AU
dc.date.available2025-08-08T04:27:07Zen_AU
dc.date.issued1995-08en_AU
dc.date.statistics2025-08-08en_AU
dc.description.abstractA novel approach for the delivery of 166Ho (t1/2 = 26.6 h) to tissue is via the in vivo decay of its 81.5 h parent, 166Dy-an in vivo generator system. A critical question for the in vivo 166Dy/166Ho generator system is whether translocation of the daughter nucleus occurs. The in vitro and in vivo integrity of the [166Dy]Dy/166Ho-DTPA complex was investigated and results indicated that no translocation of the daughter nucleus occurs subsequent to beta- decay of 166Dy. Biodistribution studies of [166Dy]Dy-DTPA showed that the ratio of 166Dy/166Ho in bone remains constant (+/- 7%) over a 20 h period, indicating no significant in vivo loss of 166Ho from the complex. Increasing the in vivo residence time of [166Dy]Dy-DTPA complex attached to HSA gave similar results. © 1995 Published by Elsevier Ltden_AU
dc.identifier.citationSmith, S. V., Di Bartolo, N., Mirzadeh, S., Lambrecht, R. M., Knapp, F. F., & Hetherington, E. L. (1995). [166Dy]dysporium/[166Ho]holmium in vivo generator. Applied Radiation and Isotopes, 46(8), 759-764. doi:10.1016/0969-8043(94)00149-Ten_AU
dc.identifier.issn0969-8043en_AU
dc.identifier.issue8en_AU
dc.identifier.journaltitleApplied Radiation and Isotopesen_AU
dc.identifier.pagination759-764en_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/16394en_AU
dc.identifier.volume46en_AU
dc.language.isoenen_AU
dc.publisherElsevieren_AU
dc.subjectDysprosium 166en_AU
dc.subjectHolmium 166en_AU
dc.subjectIn vivoen_AU
dc.subjectRadioisotope generatorsen_AU
dc.subjectTranslocationen_AU
dc.subjectDrug deliveryen_AU
dc.subjectRadiopharmaceuticalsen_AU
dc.subjectBeta decayen_AU
dc.subjectAlpha decayen_AU
dc.title[166Dy]dysprosium/[166Ho]holmium in vivo generatoren_AU
dc.typeJournal Articleen_AU
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