[166Dy]dysprosium/[166Ho]holmium in vivo generator
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Date
1995-08
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
A novel approach for the delivery of 166Ho (t1/2 = 26.6 h) to tissue is via the in vivo decay of its 81.5 h parent, 166Dy-an in vivo generator system. A critical question for the in vivo 166Dy/166Ho generator system is whether translocation of the daughter nucleus occurs. The in vitro and in vivo integrity of the [166Dy]Dy/166Ho-DTPA complex was investigated and results indicated that no translocation of the daughter nucleus occurs subsequent to beta- decay of 166Dy. Biodistribution studies of [166Dy]Dy-DTPA showed that the ratio of 166Dy/166Ho in bone remains constant (+/- 7%) over a 20 h period, indicating no significant in vivo loss of 166Ho from the complex. Increasing the in vivo residence time of [166Dy]Dy-DTPA complex attached to HSA gave similar results. © 1995 Published by Elsevier Ltd
Description
Keywords
Dysprosium 166, Holmium 166, In vivo, Radioisotope generators, Translocation, Drug delivery, Radiopharmaceuticals, Beta decay, Alpha decay
Citation
Smith, S. V., Di Bartolo, N., Mirzadeh, S., Lambrecht, R. M., Knapp, F. F., & Hetherington, E. L. (1995). [166Dy]dysporium/[166Ho]holmium in vivo generator. Applied Radiation and Isotopes, 46(8), 759-764. doi:10.1016/0969-8043(94)00149-T