Transforming spirulina maxima biomass into ultrathin bioactive coatings using an atmospheric plasma jet: a new approach to healing of infected wounds

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dc.contributor.authorPham, Ten_AU
dc.contributor.authorNguyen, TTen_AU
dc.contributor.authorNguyen, NHen_AU
dc.contributor.authorHayles, Aen_AU
dc.contributor.authorLi, WSen_AU
dc.contributor.authorPham, DQen_AU
dc.contributor.authorNguyen, CKen_AU
dc.contributor.authorNguyen, Ten_AU
dc.contributor.authorVongsvivut, JPen_AU
dc.contributor.authorNinan, Nen_AU
dc.contributor.authorSabri, YMen_AU
dc.contributor.authorZhang, Wen_AU
dc.contributor.authorVasiliev, Ken_AU
dc.contributor.authorTruong, VKen_AU
dc.date.accessioned2024-02-21T23:23:45Zen_AU
dc.date.available2024-02-21T23:23:45Zen_AU
dc.date.issued2023-09-15en_AU
dc.date.statistics2023-12-15en_AU
dc.description.abstractThe challenge of wound healing, particularly in patients with comorbidities such as diabetes, is intensified by wound infection and the accelerating problem of bacterial resistance to current remedies such as antibiotics and silver. One promising approach harnesses the bioactive and antibacterial compound C-phycocyanin from the microalga Spirulina maxima. However, the current processes of extracting this compound and developing coatings are unsustainable and difficult to achieve. To circumvent these obstacles, a novel, sustainable argon atmospheric plasma jet (Ar-APJ) technology that transforms S. maxima biomass into bioactive coatings is presented. This Ar-APJ can selectively disrupt the cell walls of S. maxima, converting them into bioactive ultrathin coatings, which are found to be durable under aqueous conditions. The findings demonstrate that Ar-APJ-transformed bioactive coatings show better antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa. Moreover, these coatings exhibit compatibility with macrophages, induce an anti-inflammatory response by reducing interleukin 6 production, and promote cell migration in keratinocytes. This study offers an innovative, single-step, sustainable technology for transforming microalgae into bioactive coatings. The approach reported here has immense potential for the generation of bioactive coatings for combating wound infections and may offer a significant advance in wound care research and application. © 2023 The Authors. Small published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License.en_AU
dc.description.sponsorshipT.P. and T.T.N. contributed equally to this work. K.V. thanks NHMRC for Fellowship GNT1194466 and ARC for grant DP220103543. V.K.T. thanks for the support from Flinders Foundation Health Seed Grant. The authors acknowledge the facilities and the scientific and technical assistance of Microscopy Australia and the Australian National Fabrication Facility (ANFF) under the National Collaborative Research Infrastructure Strategy, at the South Australian Regional Facility, Flinders Microscopy and Microanalysis, Flinders University. The authors would like to thank the RMIT Microscopy and Microanalysis Facility (RMMF). This research was undertaken on the IR microspectroscopy beamline at the Australian Synchrotron, part of ANSTO. Open access publishing facilitated by Flinders University, as part of the Wiley - Flinders University agreement via the Council of Australian University Librarians.en_AU
dc.identifier.articlenumber2305469en_AU
dc.identifier.citationPham, T., Nguyen, T. T., Nguyen, N. H., Hayles, A., Li, W., Pham, D. Q., Nguyen, C. K., Nguyen, T., Vongsvivut, J., Ninan, N., Sabri, Y. M., Zhasng, W., Vasiliev, K. & Truong, V. K. (2023). Transforming spirulina maxima biomass into ultrathin bioactive coatings using an atmospheric plasma jet: a new approach to healing of infected wounds. Small, 2305469, (Early View). doi:10.1002/smll.202305469en_AU
dc.identifier.issn1613-6829en_AU
dc.identifier.journaltitleSmallen_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/15376en_AU
dc.identifier.volumeEarly Viewen_AU
dc.language.isoenen_AU
dc.publisherWileyen_AU
dc.relation.urihttps://doi.org/10.1002/smll.202305469en_AU
dc.subjectPlasma jetsen_AU
dc.subjectCoatingsen_AU
dc.subjectWoundsen_AU
dc.subjectHealingen_AU
dc.subjectAnti-infective Agentsen_AU
dc.subjectBacteriaen_AU
dc.titleTransforming spirulina maxima biomass into ultrathin bioactive coatings using an atmospheric plasma jet: a new approach to healing of infected woundsen_AU
dc.typeJournal Articleen_AU
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