Transforming spirulina maxima biomass into ultrathin bioactive coatings using an atmospheric plasma jet: a new approach to healing of infected wounds
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Date
2023-09-15
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley
Abstract
The challenge of wound healing, particularly in patients with comorbidities such as diabetes, is intensified by wound infection and the accelerating problem of bacterial resistance to current remedies such as antibiotics and silver. One promising approach harnesses the bioactive and antibacterial compound C-phycocyanin from the microalga Spirulina maxima. However, the current processes of extracting this compound and developing coatings are unsustainable and difficult to achieve. To circumvent these obstacles, a novel, sustainable argon atmospheric plasma jet (Ar-APJ) technology that transforms S. maxima biomass into bioactive coatings is presented. This Ar-APJ can selectively disrupt the cell walls of S. maxima, converting them into bioactive ultrathin coatings, which are found to be durable under aqueous conditions. The findings demonstrate that Ar-APJ-transformed bioactive coatings show better antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa. Moreover, these coatings exhibit compatibility with macrophages, induce an anti-inflammatory response by reducing interleukin 6 production, and promote cell migration in keratinocytes. This study offers an innovative, single-step, sustainable technology for transforming microalgae into bioactive coatings. The approach reported here has immense potential for the generation of bioactive coatings for combating wound infections and may offer a significant advance in wound care research and application. © 2023 The Authors. Small published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License.
Description
Keywords
Plasma jets, Coatings, Wounds, Healing, Anti-infective Agents, Bacteria
Citation
Pham, T., Nguyen, T. T., Nguyen, N. H., Hayles, A., Li, W., Pham, D. Q., Nguyen, C. K., Nguyen, T., Vongsvivut, J., Ninan, N., Sabri, Y. M., Zhasng, W., Vasiliev, K. & Truong, V. K. (2023). Transforming spirulina maxima biomass into ultrathin bioactive coatings using an atmospheric plasma jet: a new approach to healing of infected wounds. Small, 2305469, (Early View). doi:10.1002/smll.202305469