3D sensitive volume microdosimeter with improved tissue equivalency: charge collection study and its application in 12C ion therapy

This research focuses on the characterisation of a new 3D sensitive volume (SV) microdosimeter covered with polyimide – a material which closely mimics human tissue. The electrical and charge collection properties of the device were investigated and its application in 12C ion therapy were studied. Charge collection studies revealed uniform charge collection and no cross talk between adjacent SVs. To study the microdosimetric response in 12C ion therapy, the new polyimide mushroom microdosimeter were placed at various positions along the central axis of a 290 MeV/u 12C ion spread out Bragg peak (SOBP) at the Heavy Ion Medical Accelerator in Chiba (HIMAC), Japan. From these microdosimetric spectra, dose mean lineal energy $(\overline{{y}_{D})}$ and RBE10 results were obtained, with RBE10 increasing from 1.3 at the entrance to 2.7 at the end of the SOBP. The results obtained in this work show that the new generation of mushroom microdosimeters, covered with tissue equivalent polyimide material, are a useful tool for quality assurance in heavy ion therapy applications. © Open Access - CC BY - IOP Publishing Ltd.

Keywords

Microdosimetry, Animal tissues, Therapy, Bragg curve, Meetings, Electrical properties

Citation

James, B., Tran, L. T., Bolst, D., Prokopovich, D., Reinhard, M., Lerch, M., Petasecca, M., Guatelli, S., Povoli, M., Kok, A., Matsufuji, N., Jackson, M., & Rosenfeld, A. (2019). 3D sensitive volume microdosimeter with improved tissue equivalency: charge collection study and its application in 12C ion therapy. Paper presented to the Mini-Micro and Nano Dosimetry and Innovative Technologies in Radiation Oncology, MMNDITRO 2018, 6–11 February 2018, Mooloolaba, Queensland, Australia. In Journal of Physics: Conference Series, 1154(1), 012012. doi:10.1088/1742-6596/1154/1/012012

URI

https://apo.ansto.gov.au/handle/10238/15221

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