Efficient screening of cation exchange resins for radiolanthanide separations

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dc.contributor.authorVeliscek-Carolan, Jen_AU
dc.contributor.authorPellegrini, PAen_AU
dc.contributor.authorBurgess, Len_AU
dc.contributor.authorChironi, Ien_AU
dc.contributor.authorMansour, Fen_AU
dc.date.accessioned2025-12-10T22:13:08Zen_AU
dc.date.available2025-12-10T22:13:08Zen_AU
dc.date.issued2025-12en_AU
dc.date.statistics2025-12-11en_AU
dc.description.abstractThis study presents a rapid analysis method for characterizing ion exchange resins used in radiolanthanide separations. Fourier Transform Infrared Spectroscopy (FTIR) analysis, combined with manufacturer-reported bead size, allows for the prediction of resin separation efficiency. Via FTIR, four subclasses (type A-D) of commercially available strong cation exchange resins with a polystyrene-divinylbenzene (PS-DVB) polymer base were identified, with variations in the 1000–1300 cm−1 region indicating the presence or absence of sulfonate functional groups and sulfone bridges. Type A resins with functional sulfonate groups showed superior separation resolution in the three-lanthanide system (dysprosium, terbium and gadolinium) as compared to other subclasses. Type B resins showed evidence of sulfone bridges, which reduce the availability of sulfonate functional groups and resulted in reduced lanthanide separation resolution. Type C and D resins showed minimal sulfonate functional groups and this corresponded to reduced analyte retention. Additionally, the DVB density of ion exchange resins was found to correlate with the process time of their chromatographic separation, although separation resolution appeared unaffected by cross-linking. This novel method of resin evaluation combining bead size and FTIR enables a reduction in the time, cost and waste generated relative to chromatographic evaluation. Thus, this approach offers a significant improvement in practical efficiency for evaluating the utility of PS-DVB resins in chromatographic separations. © 2025 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY licence 4.0en_AU
dc.identifier.articlenumber116078en_AU
dc.identifier.citationVeliscek-Carolan, J., Pellegrini, P., Burgess, L., Chironi, I., & Mansour, F. (2025). Efficient screening of cation exchange resins for radiolanthanide separations. Microchemical Journal, 219, 116078. doi:10.1016/j.microc.2025.116078en_AU
dc.identifier.issn0026-265Xen_AU
dc.identifier.journaltitleMicrochemical Journalen_AU
dc.identifier.urihttps://doi.org/10.1016/j.microc.2025.116078en_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/16771en_AU
dc.identifier.volume219en_AU
dc.languageEnglishen_AU
dc.language.isoenen_AU
dc.publisherElsevieren_AU
dc.subjectCross-linkingen_AU
dc.subjectSeparation processesen_AU
dc.subjectSulfonatesen_AU
dc.subjectIon Exchange Chromatographyen_AU
dc.subjectEmission spectraen_AU
dc.subjectRadiopharmaceuticalsen_AU
dc.subjectNeoplasmsen_AU
dc.subjectTumor cellsen_AU
dc.subjectSolvent extractionen_AU
dc.subjectDistillationen_AU
dc.subjectIsotopesen_AU
dc.subjectRadiation dose rangesen_AU
dc.subjectPurificationen_AU
dc.subjectRaman spectroscopyen_AU
dc.subjectResinsen_AU
dc.titleEfficient screening of cation exchange resins for radiolanthanide separationsen_AU
dc.typeJournal Articleen_AU
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