An intra-pancreatic and hepatic nude mouse cancer xenograft model for boron neutron capture therapy

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dc.contributor.authorMallesch, JLen_AU
dc.contributor.authorChiaraviglio, Den_AU
dc.contributor.authorAllen, BJen_AU
dc.contributor.authorMoore, DEen_AU
dc.date.accessioned2026-01-08T00:41:22Zen_AU
dc.date.available2026-01-08T00:41:22Zen_AU
dc.date.issued1993en_AU
dc.date.statistics2026-01-08en_AU
dc.descriptionPhysical copy held by ANSTO Library at DDC. 616.9940642/3en_AU
dc.description.abstractThe cure of many cancers depends on their early detection and surgical excision. This is not the case for primary pancreatic cancer and hepatic metastases which have very poor prognoses. Cancer cells infiltrate the liver and current treatment protocols are unable to selectively kill these cells. Even though the affected organs are deep seated in the patient, NCT with an epithermal beam of the appropriate characteristics, used externally or intra-operatively, might represent an approach to the treatment of the cancers. In the development of an animal model system, the subcutaneous inoculation of pancreatic and hepatic tumour cell lines into nude mice has many limitations. An alternative approach is to inoculate internal organs with cancer cells to produce a different, but potentially more realistic, behaviour of that tumour type. This may then provide a superior indication of the potential for targeting these cancers with boron compounds. © Plenum Pressen_AU
dc.identifier.booktitleAdvances in Capture Therapy for Canceren_AU
dc.identifier.citationMallesch, J. L., Chiaraviglio, D., Allen, B. J. & Moore, D. E. (1993). An intra-pancreatic and hepatic nude mouse cancer xenograft model for boron neutron capture therapy. Paper presented to the Fifth International Symposium on Neutron Capture Therapy for Cancer, September 14-17, Columbus, Ohio, USA. In Soloway, A. H., Barth, R. F., & Carpenter, D. E. (Eds.) Advances in Neutron Capture Therapy, (pp. 547-550). Boston, MA : Plenum Press.en_AU
dc.identifier.conferenceenddate1992-09-17en_AU
dc.identifier.conferencenameFifth International Symposium on Neutron Capture Therapy for Canceren_AU
dc.identifier.conferenceplaceColumbus, Ohioen_AU
dc.identifier.conferencestartdate1992-09-16en_AU
dc.identifier.editorsSoloway, A. H., Barth, R. F., & Carpenter, D. E.en_AU
dc.identifier.isbn0306445670en_AU
dc.identifier.pagination547-550en_AU
dc.identifier.placeofpublicationNew York, USAen_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/16840en_AU
dc.language.isoenen_AU
dc.publisherPlenum Pressen_AU
dc.subjectNeutron capture therapyen_AU
dc.subjectBoron 10en_AU
dc.subjectNeoplasmsen_AU
dc.subjectPancreasen_AU
dc.subjectMetastasesen_AU
dc.subjectTumor cellsen_AU
dc.subjectDetectionen_AU
dc.subjectOrgansen_AU
dc.subjectBeamsen_AU
dc.subjectBoron compoundsen_AU
dc.titleAn intra-pancreatic and hepatic nude mouse cancer xenograft model for boron neutron capture therapyen_AU
dc.typeConference Paperen_AU
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