An intra-pancreatic and hepatic nude mouse cancer xenograft model for boron neutron capture therapy
No Thumbnail Available
Date
1993
Journal Title
Journal ISSN
Volume Title
Publisher
Plenum Press
Abstract
The cure of many cancers depends on their early detection and surgical excision. This is not the case for primary pancreatic cancer and hepatic metastases which have very poor prognoses. Cancer cells infiltrate the liver and current treatment protocols are unable to selectively kill these cells. Even though the affected organs are deep seated in the patient, NCT with an epithermal beam of the appropriate characteristics, used externally or intra-operatively, might represent an approach to the treatment of the cancers. In the development of an animal model system, the subcutaneous inoculation of pancreatic and hepatic tumour cell lines into nude mice has many limitations. An alternative approach is to inoculate internal organs with cancer cells to produce a different, but potentially more realistic, behaviour of that tumour type. This may then provide a superior indication of the potential for targeting these cancers with boron compounds. © Plenum Press
Description
Physical copy held by ANSTO Library at DDC. 616.9940642/3
Keywords
Neutron capture therapy, Boron 10, Neoplasms, Pancreas, Metastases, Tumor cells, Detection, Organs, Beams, Boron compounds
Citation
Mallesch, J. L., Chiaraviglio, D., Allen, B. J. & Moore, D. E. (1993). An intra-pancreatic and hepatic nude mouse cancer xenograft model for boron neutron capture therapy. Paper presented to the Fifth International Symposium on Neutron Capture Therapy for Cancer, September 14-17, Columbus, Ohio, USA. In Soloway, A. H., Barth, R. F., & Carpenter, D. E. (Eds.) Advances in Neutron Capture Therapy, (pp. 547-550). Boston, MA : Plenum Press.