Systemic effects of synchrotron radiation

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dc.contributor.authorVentura, Jen_AU
dc.contributor.authorSprung, CNen_AU
dc.contributor.authorForrester, HBen_AU
dc.contributor.authorPalazzolo, JSen_AU
dc.contributor.authorIvashkevich, Aen_AU
dc.contributor.authorStevenson, AWen_AU
dc.contributor.authorHall, CJen_AU
dc.contributor.authorGeorgakilas, AGen_AU
dc.contributor.authorLobachevsky, PNen_AU
dc.contributor.authorMartin, OAen_AU
dc.date.accessioned2024-01-11T07:21:28Zen_AU
dc.date.available2024-01-11T07:21:28Zen_AU
dc.date.issued2018-02-06en_AU
dc.date.statistics2023-07-04en_AU
dc.description.abstractA change in an organ or tissue distant from the irradiated region was termed the radiation-induced abscopal effect (RIAE). It is not known how radiation settings affect non-targeted normal tissues and therefore the risk of radiation-related adverse abscopal effects. In a recent study, we examined abscopal effects of microbeam radiotherapy (MRT) and broad beam (BB) configurations, in mice that were locally exposed to a very short pulse of a high dose-rate synchrotron beam utilizing the Imaging and Medical Beamline (IMBL) at the Australian Synchrotron. Here we summarise this study. Oxidative DNA damage was elevated in a wide variety of unirradiated normal tissues. Out-of-field duodenum showed a trend for elevated apoptotic cell death under most irradiation conditions, however, double-strand breaks (DSBs) elevated only after exposure to lower doses. These genotoxic events were accompanied by changes in concentrations of several plasma cytokines and in frequencies of macrophages, neutrophils and T-lymphocytes in duodenum. Overall, systemic radiation responses were independent of dose, time post-irradiation, and radiation modality. These findings have implications for the planning of therapeutic and diagnostic radiation treatment to reduce the risk of radiation-related adverse systemic effects. ©2019 The Authors. Open Access CC-BY.en_AU
dc.identifier.articlenumber012028en_AU
dc.identifier.citationVentura, J., Sprung, C. N., Forrester, H. B., Palazzolo, J. S., Ivashkevich, A., Stevenson, A. W., Hall, C. J., Georgakilas, A. G., Lobachevsky, P. N., & Martin, O. A. (2019). Systemic effects of synchrotron radiation. Paper presented to Mini-Micro-Nano-Dosimetry and Innovative Technologies in Radiation Oncology Workshops, MMND & ITRO 2018, 6–11 February 2018, Mooloolaba, Queensland, Australia. In Journal of Physics: Conference Series, 1154(1), 012028. doi:10.1088/1742-6596/1154/1/012028en_AU
dc.identifier.conferenceenddate2018-02-11en_AU
dc.identifier.conferencenameMini-Micro-Nano-Dosimetry and Innovative Technologies in Radiation Oncology Workshops, MMND & ITRO 2018en_AU
dc.identifier.conferenceplaceMooloolaba, Queenslanden_AU
dc.identifier.conferencestartdate2018-02en_AU
dc.identifier.isbn1742-6596en_AU
dc.identifier.issue1en_AU
dc.identifier.journaltitleJournal of Physics: Conference Seriesen_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/15323en_AU
dc.identifier.volume1154en_AU
dc.language.isoenen_AU
dc.publisherInstitute of Physics Publishingen_AU
dc.relation.urihttps://iopscience.iop.org/article/10.1088/1742-6596/1154/1/012028en_AU
dc.subjectAbscopal Radiation Effectsen_AU
dc.subjectRadiotherapyen_AU
dc.subjectSynchrotronsen_AU
dc.subjectAustralian organizationsen_AU
dc.subjectDNAen_AU
dc.subjectDamageen_AU
dc.subjectApoptosisen_AU
dc.subjectMacrophagesen_AU
dc.subjectNeutrophilsen_AU
dc.subjectTherapeutic usesen_AU
dc.subjectDosesen_AU
dc.subjectPlasmaen_AU
dc.titleSystemic effects of synchrotron radiationen_AU
dc.typeConference Abstracten_AU
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