Systemic effects of synchrotron radiation

A change in an organ or tissue distant from the irradiated region was termed the radiation-induced abscopal effect (RIAE). It is not known how radiation settings affect non-targeted normal tissues and therefore the risk of radiation-related adverse abscopal effects. In a recent study, we examined abscopal effects of microbeam radiotherapy (MRT) and broad beam (BB) configurations, in mice that were locally exposed to a very short pulse of a high dose-rate synchrotron beam utilizing the Imaging and Medical Beamline (IMBL) at the Australian Synchrotron. Here we summarise this study. Oxidative DNA damage was elevated in a wide variety of unirradiated normal tissues. Out-of-field duodenum showed a trend for elevated apoptotic cell death under most irradiation conditions, however, double-strand breaks (DSBs) elevated only after exposure to lower doses. These genotoxic events were accompanied by changes in concentrations of several plasma cytokines and in frequencies of macrophages, neutrophils and T-lymphocytes in duodenum. Overall, systemic radiation responses were independent of dose, time post-irradiation, and radiation modality. These findings have implications for the planning of therapeutic and diagnostic radiation treatment to reduce the risk of radiation-related adverse systemic effects. ©2019 The Authors. Open Access CC-BY.

Keywords

Abscopal Radiation Effects, Radiotherapy, Synchrotrons, Australian organizations, DNA, Damage, Apoptosis, Macrophages, Neutrophils, Therapeutic uses, Doses, Plasma

Citation

Ventura, J., Sprung, C. N., Forrester, H. B., Palazzolo, J. S., Ivashkevich, A., Stevenson, A. W., Hall, C. J., Georgakilas, A. G., Lobachevsky, P. N., & Martin, O. A. (2019). Systemic effects of synchrotron radiation. Paper presented to Mini-Micro-Nano-Dosimetry and Innovative Technologies in Radiation Oncology Workshops, MMND & ITRO 2018, 6–11 February 2018, Mooloolaba, Queensland, Australia. In Journal of Physics: Conference Series, 1154(1), 012028. doi:10.1088/1742-6596/1154/1/012028

URI

https://apo.ansto.gov.au/handle/10238/15323

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