Piloting Rasch model scoring of the national eye institute visual function questionnaire in uveitis

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dc.contributor.authorGittel, Len_AU
dc.contributor.authorLi, JQen_AU
dc.contributor.authorDell, Jen_AU
dc.contributor.authorWintergerst, MWMen_AU
dc.contributor.authorHeinz, Cen_AU
dc.contributor.authorFinger, RPen_AU
dc.contributor.authorTerheyden, JHen_AU
dc.date.accessioned2024-12-05T23:31:29Zen_AU
dc.date.available2024-12-05T23:31:29Zen_AU
dc.date.issued2024-04-16en_AU
dc.date.statistics2024-11-27en_AU
dc.description.abstractIntroduction The National Eye Institute Visual Function Questionnaire (NEI VFQ) is a common patient-reported outcome measure (PROM) in uveitis trials. Its psychometric properties using state-of-the-art scoring based on Rasch models, a latent trait model that improves accuracy of PROMs assessment, has not yet been investigated. Methods The study participants were recruited online from uveitis patient organizations, where individuals self-reported their uveitis diagnosis and visual acuity level. These participants then completed the NEI VFQ-25. The visual function (VF) and socioemotional (SE) subscales were psychometrically analysed in terms of item fit, targeting, internal consistency, dimensionality, and differential item functioning (DIF), using Rasch models. Criterion validity was examined based on associations between NEI VFQ person measures and recent visual acuity (VA) levels. Results Ninety-nine participants recruited online from uveitis patient organizations (68 women, 31 men; mean age 50 ± 15 years; 46.5% self-reported receiving systematic therapy for uveitis, 0.6% NEI VFQ-25 missing data) were included. The mean difficulty of items was lower than the average person ability. None of the items demonstrated misfit to an extent that would induce noise into the measurement. The consistency metrics person reliability and person separation index of the subscales were 0.85 and 2.34 (NEI VFQ-VF), 0.86 and 2.52 (NEI VFQ-SE), respectively. There was no evidence of multidimensionality and none of the items showed DIF by gender. The differences between item and person measures were 1.44 (NEI VFQ-VF) and 1.03 (NEI VFQ-SE). NEI VFQ-25 person measures were significantly lower in participants with visual impairment (all p values ≤ 0.007). Conclusion Rasch model-based scoring of the re-engineered NEI VFQ-25 demonstrates acceptable internal consistency, item fit and construct validity for assessing two key domains of quality of life in individuals self-reporting uveitis. The PROM was targeted at a higher level of difficulty than present in our heterogeneous sample. © 2024 © The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International Licence.en_AU
dc.description.sponsorshipOpen Access funding enabled and organized by Projekt DEAL. Open Access funding enabled and organized by Projekt DEAL. This research was funded by the German Ophthalmologic Society (Deutsche Ophthalmologische Gesellschaft, DOG), grant number FF 2019, project number FF 2020.en_AU
dc.format.mediumElectronicen_AU
dc.identifier.articlenumber16en_AU
dc.identifier.citationGittel, L., Li, J. Q., Dell, J., Wintergerst, M. W. M., Heinz, C., Finger, R. P., & Terheyden, J. H. (2024). Piloting Rasch model scoring of the national eye institute visual function questionnaire in uveitis. Journal of Ophthalmic Inflammation and Infection, 14(1), 16. doi:10.1186/s12348-024-00398-xen_AU
dc.identifier.issn1869-5760en_AU
dc.identifier.issue1en_AU
dc.identifier.journaltitleJournal of Ophthalmic Inflammation and Infectionen_AU
dc.identifier.pagination16-en_AU
dc.identifier.urihttps://doi.org/10.1186/s12348-024-00398-xen_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/15794en_AU
dc.identifier.volume14en_AU
dc.languageEnglishen_AU
dc.language.isoenen_AU
dc.publisherSpringer Natureen_AU
dc.subjectAccuracyen_AU
dc.subjectIndexesen_AU
dc.subjectSamplersen_AU
dc.subjectTestingen_AU
dc.subjectMetricsen_AU
dc.subjectReliabilityen_AU
dc.titlePiloting Rasch model scoring of the national eye institute visual function questionnaire in uveitisen_AU
dc.typeJournal Articleen_AU
dcterms.dateAccepted2024-04-07en_AU
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