Neutron capture therapy research in Australia

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dc.contributor.authorAllen. BJen_AU
dc.date.accessioned2025-11-21T06:48:46Zen_AU
dc.date.available2025-11-21T06:48:46Zen_AU
dc.date.issued1989en_AU
dc.date.statistics2025-11-11en_AU
dc.descriptionPhysical copy held by ANSTO Library at DDC: 616.99477/3 Also held as part of a journal Pigment Cell Research Vol. 2, No. 4 (1989) at the same DDC number.en_AU
dc.description.abstractNeutron capture therapy research in Australia has continued to grow since the first Australia-Japan workshop in April, 1986. The support base has broadened and the wide range of contributing laboratories includes universities, research institutes, and hospitals. Considerable progress has been made in boron chemistry--an accurate boron assay technique has been developed, boron analogues of chlorpromazine and thiouracil have been synthesised or nearly so, and decaborane conjugation with monoclonal antibodies has been achieved to the required loadings. In vitro cell survival experiments are proceeding in the Moata reactor using human melanoma and mouse cell lines incubated with enriched boronophenylalanine and boron tetraphenyl porphyrins. Electron microscopy examination of radiation damaged morphology shows considerable differences between cell lines. Progress with the nude mouse human melanoma model has been slow because of the lack of a reliable in vivo melanotic melanoma line, and the B16 mouse line is found to be more efficacious. Tailored beam calculations for the 10 MW HIFAR reactor indicate the difficulty of obtaining a suitable therapeutic beam because of the generated gamma dose in the beam filters. A new approach to NCT utilises the enormous cross section of 157Gd and the induced-Auger effect which has been shown to cause double strand breaks in circular DNA. © Alan R. Liss Inc.en_AU
dc.identifier.booktitleMelanoma neutron capture therapy : proceedings of 2nd Japan-Australia International Workshop on Thermal Neutron Capture Therapy for Malignant Melanoma, Kobe, September 23-26, 1987en_AU
dc.identifier.citationAllen, B. J. (1989). Neutron capture therapy research in Australia. Paper prsented to the 2nd Japan-Australia International Workshop on Thermal Neutron Capture Therapy for Malignant Melanoma, Kobe, September 23-26, 1987. In Mishima, Y. (ed.). Melanoma neutron capture therapy : proceedings of 2nd Japan-Australia International Workshop on Thermal Neutron Capture Therapy for Malignant Melanoma, Kobe, September 23-26, 1987, (pp. 235-239). New York : Alan R. Liss.en_AU
dc.identifier.conferenceenddate1987-09-26en_AU
dc.identifier.conferencename2nd Japan-Australia International Workshop on Thermal Neutron Capture Therapy for Malignant Melanomaen_AU
dc.identifier.conferenceplaceKobeen_AU
dc.identifier.conferencestartdate1987-09-23en_AU
dc.identifier.editorsYukata Mishimaen_AU
dc.identifier.issn0893-5785en_AU
dc.identifier.pagination235-239en_AU
dc.identifier.placeofpublicationNew Worken_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/16732en_AU
dc.language.isoenen_AU
dc.publisherAlan R. Liss, Incen_AU
dc.relation.ispartofseriesSINCT-REP; 1en_AU
dc.subjectAustraliaen_AU
dc.subjectBoron compoundsen_AU
dc.subjectDNAen_AU
dc.subjectElectron microscopyen_AU
dc.subjectExperimental neoplasmsen_AU
dc.subjectGadoliniumen_AU
dc.subjectGadolinium 157en_AU
dc.subjectMelanomasen_AU
dc.subjectMiceen_AU
dc.subjectNeutron capture therapyen_AU
dc.subjectNeutronsen_AU
dc.subjectResearch programsen_AU
dc.subjectReviewsen_AU
dc.subjectSurvival Timeen_AU
dc.subjectStable isotopesen_AU
dc.subjectRadiotherapyen_AU
dc.subjectTherapyen_AU
dc.titleNeutron capture therapy research in Australiaen_AU
dc.typeConference Paperen_AU
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