Neutron capture therapy research in Australia
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Date
1989
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Alan R. Liss, Inc
Abstract
Neutron capture therapy research in Australia has continued to grow since the first Australia-Japan workshop in April, 1986. The support base has broadened and the wide range of contributing laboratories includes universities, research institutes, and hospitals. Considerable progress has been made in boron chemistry--an accurate boron assay technique has been developed, boron analogues of chlorpromazine and thiouracil have been synthesised or nearly so, and decaborane conjugation with monoclonal antibodies has been achieved to the required loadings. In vitro cell survival experiments are proceeding in the Moata reactor using human melanoma and mouse cell lines incubated with enriched boronophenylalanine and boron tetraphenyl porphyrins. Electron microscopy examination of radiation damaged morphology shows considerable differences between cell lines. Progress with the nude mouse human melanoma model has been slow because of the lack of a reliable in vivo melanotic melanoma line, and the B16 mouse line is found to be more efficacious. Tailored beam calculations for the 10 MW HIFAR reactor indicate the difficulty of obtaining a suitable therapeutic beam because of the generated gamma dose in the beam filters. A new approach to NCT utilises the enormous cross section of 157Gd and the induced-Auger effect which has been shown to cause double strand breaks in circular DNA. © Alan R. Liss Inc.
Description
Physical copy held by ANSTO Library at DDC: 616.99477/3
Also held as part of a journal Pigment Cell Research Vol. 2, No. 4 (1989) at the same DDC number.
Keywords
Australia, Boron compounds, DNA, Electron microscopy, Experimental neoplasms, Gadolinium, Gadolinium 157, Melanomas, Mice, Neutron capture therapy, Neutrons, Research programs, Reviews, Survival Time, Stable isotopes, Radiotherapy, Therapy
Citation
Allen, B. J. (1989). Neutron capture therapy research in Australia. Paper prsented to the 2nd Japan-Australia International Workshop on Thermal Neutron Capture Therapy for Malignant Melanoma, Kobe, September 23-26, 1987. In Mishima, Y. (ed.). Melanoma neutron capture therapy : proceedings of 2nd Japan-Australia International Workshop on Thermal Neutron Capture Therapy for Malignant Melanoma, Kobe, September 23-26, 1987, (pp. 235-239). New York : Alan R. Liss.