High-density lipoprotein function is modulated by the SARS-CoV-2 spike protein in a lipid-type dependent manner

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dc.contributor.authorCorrea, YBen_AU
dc.contributor.authorDel Giuduce, Ren_AU
dc.contributor.authorWaldie, Sen_AU
dc.contributor.authorThépaut, Men_AU
dc.contributor.authorGerelli, Yen_AU
dc.contributor.authorMoulin, Men_AU
dc.contributor.authorDelauney, Cen_AU
dc.contributor.authorFieschi, Fen_AU
dc.contributor.authorHaertlein, Men_AU
dc.contributor.authorLe Brun, APen_AU
dc.contributor.authorForsyth, VTen_AU
dc.contributor.authorMoir, Men_AU
dc.contributor.authorRussell, RAen_AU
dc.contributor.authorDarwish, TAen_AU
dc.contributor.authorBrinck, Jen_AU
dc.contributor.authorWodaje, Ten_AU
dc.contributor.authorJansen, Men_AU
dc.contributor.authorMartín, Cen_AU
dc.contributor.authorRoosen-Runge, Fen_AU
dc.contributor.authorCárdenas, Men_AU
dc.contributor.authorMicciulla, Sen_AU
dc.contributor.authorPichler, Hen_AU
dc.date.accessioned2023-11-21T00:50:39Zen_AU
dc.date.available2023-11-21T00:50:39Zen_AU
dc.date.issued2023-09en_AU
dc.date.statistics2023-07-21en_AU
dc.descriptionThe author Samantha Micciulla has been misspelt in the citation as Micciula, S. Her name generally appears as Micculla elsewhere.en_AU
dc.description.abstractThere is a close relationship between the SARS-CoV-2 virus and lipoproteins, in particular high-density lipoprotein (HDL). The severity of the coronavirus disease 2019 (COVID-19) is inversely correlated with HDL plasma levels. It is known that the SARS-CoV-2 spike (S) protein binds the HDL particle, probably depleting it of lipids and altering HDL function. Based on neutron reflectometry (NR) and the ability of HDL to efflux cholesterol from macrophages, we confirm these observations and further identify the preference of the S protein for specific lipids and the consequent effects on HDL function on lipid exchange ability. Moreover, the effect of the S protein on HDL function differs depending on the individuals lipid serum profile. Contrasting trends were observed for individuals presenting low triglycerides/high cholesterol serum levels (LTHC) compared to high triglycerides/high cholesterol (HTHC) or low triglycerides/low cholesterol serum levels (LTLC). Collectively, these results suggest that the S protein interacts with the HDL particle and, depending on the lipid profile of the infected individual, it impairs its function during COVID-19 infection, causing an imbalance in lipid metabolism. © Crown Copyright 2023. Published by Elsevier Inc. Open Access - CC BY licence 4.0.en_AU
dc.description.sponsorshipMC, YC, and SW acknowledge economic support from the Swedish Research Council (grants number 2018-03990 and 2018-04833). MC thanks the Wennergren Foundation for funding (grant number SSh2020-0005). IBS acknowledges integration into the Interdisciplinary Research Institute of Grenoble (IRIG, CEA). VTF acknowledges support from the UK Engineering and Physical Sciences Council (EPSRC) which funded the creation of the Deuteration Laboratory within the Life Sciences Group at the ILL [GR/R99393/01 and EP/C015452/1]. This work used the platforms of the Grenoble Instruct-ERIC center (ISBG; UAR 3518 CNRS-CEA-UGA-EMBL) within the Grenoble Partnership for Structural Biology (PSB), supported by FRISBI (ANR-10-INBS-0005-02) and GRAL, financed within the University Grenoble Alpes graduate school (Ecoles Universitaires de Recherche) CBH-EUR-GS (ANR-17-EURE-0003). Operations for the Spatz neutron reflectometerand the National Deuteration Facility at ANSTO are supported by the National Characterisation Research Infrastructure Strategy (NCRIS), an Australian Government initiative.en_AU
dc.identifier.citationCorrea, Y., Del Giudice, R., Waldie, S., Thépaut, M., Micciula, S., Gerelli, Y., Moulin, M., Delaunay, C., Fieschi, F., Pichler, H., Haertlein, M., Forsyth, V. T., Le Brun, A., Moir, M., Russell, R. A., Darwish, T., Brinck, J., Wodaje, T., Jansen, M., Martín, C., Roosen-Runge, F., & Cárdenas, M. (2023). High-density lipoprotein function is modulated by the SARS-CoV-2 spike protein in a lipid-type dependent manner. Journal of Colloid and Interface Science, 645, 627-638. doi:10.1016/j.jcis.2023.04.137en_AU
dc.identifier.issn0021-9797en_AU
dc.identifier.journaltitleJournal of Colloid and Interface Scienceen_AU
dc.identifier.pagination627-638en_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/15216en_AU
dc.identifier.volume645en_AU
dc.language.isoenen_AU
dc.publisherElsevier B. V.en_AU
dc.relation.urihttps://doi.org/10.1016/j.jcis.2023.04.137en_AU
dc.subjectCoronavirusesen_AU
dc.subjectProteinsen_AU
dc.subjectDeuterationen_AU
dc.subjectCholesterolen_AU
dc.subjectLipidsen_AU
dc.subjectNeutron reflectorsen_AU
dc.subjectMetabolismen_AU
dc.subjectLipoproteinsen_AU
dc.subjectTriglyceridesen_AU
dc.subjectImmune Serumsen_AU
dc.titleHigh-density lipoprotein function is modulated by the SARS-CoV-2 spike protein in a lipid-type dependent manneren_AU
dc.typeJournal Articleen_AU
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