Ftir spectrometry for the assay of polyhedral boron compounds in plasma
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Date
1993
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Publisher
Plenum Press
Abstract
Many of the new compounds being developed for neutron capture therapy contain the icosahedral boron cage structure with up to 12 boron atoms. The infrared spectrum of each compound provides a fingerprint which can be used as an aid in their identification.1 In particular, the most intense and identifiable band is the boron-hydrogen stretching vibration at about 2500 cm-1. This high energy region is relatively free from overlap due to absorption by solvent and other molecules in the system. Additionally, the B-H stretch band is not significantly influenced by interaction from the surrounding atoms. The advent of Fourier Transform infrared instrumentation (FTIR) has enhanced the capabilities of this spectroscopic technique, especially in the area of sensitivity and speed of assay. Thus FTIR is used routinely, for example to confirm the introduction of the boron cluster in the synthesis of new polyhedral boron compounds,2 and in characterising reconstituted boronated low density lipoproteins.3 Very recently, FTIR was applied to the determination of sodium borocaptate (BSH) in aqueous solution and urine. © Plenum Press
Description
Physical copy held by ANSTO Library at DDC. 616.9940642/3.
Keywords
Immune Serums, Boron, Boron compounds, Fourier transform spectrometers, Sodium, Aqueous solutions, Urine
Citation
Moore, D. E., Setiawan, Y., Blagojevic, N., & Allen, B. J. (1993). Ftir spectrometry for the assay of polyhedral boron compounds in plasma. Paper presented to the Fifth International Symposium on Neutron Capture Therapy for Cancer, September 14-17, Columbus, Ohio, USA. In Soloway, A. H., Barth, R. F., Carpenter, D. E. (Eds.) Advances in Neutron Capture Therapy, (pp. 413-417). Boston, MA : Plenum Press.