Please use this identifier to cite or link to this item: https://apo.ansto.gov.au/dspace/handle/10238/9309
Title: Synergistic effect between maternal infection and adolescent cannabinoid exposure on serotonin 5HT1A receptor binding in the hippocampus: testing the “two hit” hypothesis for the development of schizophrenia
Authors: Dalton, VS
Verdurand, M
Walker, A
Hodgson, DM
Zavitsanou, K
Keywords: Pregnancy
Adolescents
Serotonin
Drugs
Hippocampus
Mental disorders
Neurology
Animals
Rats
Issue Date: 7-Jun-2012
Publisher: Hindawi
Citation: Dalton, V. S., Verdurand, M., Walker, A., Hodgson, D. M., & Zavitsanou, K. (2012).Synergistic effect between maternal infection and adolescent cannabinoid exposure on serotonin 5HT1A receptor binding in the hippocampus: testing the “two hit” hypothesis for the development of schizophrenia. International Scholarly Research Notices, 2012. doi:10.5402/2012/451865
Abstract: Infections during pregnancy and adolescent cannabis use have both been identified as environmental risk factors for schizophrenia. We combined these factors in an animal model and looked at their effects, alone and in combination, on serotonin 5 H T 1 A receptor binding (5 H T 1 A R ) binding longitudinally from late adolescence to adulthood. Pregnant rats were exposed to the viral mimic poly I:C on embryonic day 15. Adolescent offspring received daily injections of the cannabinoid HU210 for 14 days starting on postnatal day (PND) 35. Hippocampal and cortical 5 H T 1 A R binding was quantified autoradiographically using [3H]8-OH-DPAT, in late adolescent (PND 55), young adult (PND 65) and adult (PND 90) rats. Descendants of poly I:C treated rats showed significant increases of 15–18% in 5 H T 1 A R in the hippocampus (CA1) compared to controls at all developmental ages. Offspring of poly I:C treated rats exposed to HU210 during adolescence exhibited even greater elevations in 5 H T 1 A R (with increases of 44, 29, and 39% at PNDs 55, 65, and 90). No effect of HU210 alone was observed. Our results suggest a synergistic effect of prenatal infection and adolescent cannabinoid exposure on the integrity of the serotoninergic system in the hippocampus that may provide the neurochemical substrate for abnormal hippocampal-related functions relevant to schizophrenia. © 2012 Victoria S. Dalton et al.
Description: This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Gov't Doc #: 8705
URI: https://doi.org/10.5402/2012/451865
http://apo.ansto.gov.au/dspace/handle/10238/9309
ISSN: 2356-7872
Appears in Collections:Journal Articles

Files in This Item:
File Description SizeFormat 
451865.pdf1.88 MBAdobe PDFThumbnail
View/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.