Synergistic effect between maternal infection and adolescent cannabinoid exposure on serotonin 5HT1A receptor binding in the hippocampus: testing the “two hit” hypothesis for the development of schizophrenia

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dc.contributor.authorDalton, VSen_AU
dc.contributor.authorVerdurand, Men_AU
dc.contributor.authorWalker, Aen_AU
dc.contributor.authorHodgson, DMen_AU
dc.contributor.authorZavitsanou, Ken_AU
dc.date.accessioned2020-03-30T01:25:34Zen_AU
dc.date.available2020-03-30T01:25:34Zen_AU
dc.date.issued2012-06-07en_AU
dc.descriptionThis is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_AU
dc.description.abstractInfections during pregnancy and adolescent cannabis use have both been identified as environmental risk factors for schizophrenia. We combined these factors in an animal model and looked at their effects, alone and in combination, on serotonin 5 H T 1 A receptor binding (5 H T 1 A R ) binding longitudinally from late adolescence to adulthood. Pregnant rats were exposed to the viral mimic poly I:C on embryonic day 15. Adolescent offspring received daily injections of the cannabinoid HU210 for 14 days starting on postnatal day (PND) 35. Hippocampal and cortical 5 H T 1 A R binding was quantified autoradiographically using [3H]8-OH-DPAT, in late adolescent (PND 55), young adult (PND 65) and adult (PND 90) rats. Descendants of poly I:C treated rats showed significant increases of 15–18% in 5 H T 1 A R in the hippocampus (CA1) compared to controls at all developmental ages. Offspring of poly I:C treated rats exposed to HU210 during adolescence exhibited even greater elevations in 5 H T 1 A R (with increases of 44, 29, and 39% at PNDs 55, 65, and 90). No effect of HU210 alone was observed. Our results suggest a synergistic effect of prenatal infection and adolescent cannabinoid exposure on the integrity of the serotoninergic system in the hippocampus that may provide the neurochemical substrate for abnormal hippocampal-related functions relevant to schizophrenia. © 2012 Victoria S. Dalton et al.en_AU
dc.identifier.articlenumber451865en_AU
dc.identifier.citationDalton, V. S., Verdurand, M., Walker, A., Hodgson, D. M., & Zavitsanou, K. (2012).Synergistic effect between maternal infection and adolescent cannabinoid exposure on serotonin 5HT1A receptor binding in the hippocampus: testing the “two hit” hypothesis for the development of schizophrenia. International Scholarly Research Notices, 2012, 451865. doi:10.5402/2012/451865en_AU
dc.identifier.govdoc8705en_AU
dc.identifier.issn2356-7872en_AU
dc.identifier.journaltitleInternational Scholarly Research Noticesen_AU
dc.identifier.urihttps://doi.org/10.5402/2012/451865en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/9309en_AU
dc.identifier.volume2012en_AU
dc.language.isoenen_AU
dc.publisherHindawien_AU
dc.subjectPregnancyen_AU
dc.subjectAdolescentsen_AU
dc.subjectSerotoninen_AU
dc.subjectDrugsen_AU
dc.subjectHippocampusen_AU
dc.subjectMental disordersen_AU
dc.subjectNeurologyen_AU
dc.subjectAnimalsen_AU
dc.subjectRatsen_AU
dc.titleSynergistic effect between maternal infection and adolescent cannabinoid exposure on serotonin 5HT1A receptor binding in the hippocampus: testing the “two hit” hypothesis for the development of schizophreniaen_AU
dc.typeJournal Articleen_AU
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