Synthesis and biological characterisation of 18F-SIG343 and 18F-SIG353, novel and high selectivity σ2 radiotracers, for tumour imaging properties

Sigma2 (σ2) receptors are highly expressed in cancer cell lines and in tumours. Two novel selective 18F-phthalimido σ2 ligands, 18F-SIG343 and 18F-SIG353, were prepared and characterised for their potential tumour imaging properties. © 2013 Nguyen et al.; licensee Springer.
In vivo, Proteins, Receptors, Neoplasms, Channeling, Tracer techniques, Metabolites
Nguyen, V. H., Pham, T., Fookes, C., Berghofer, P., Greguric, I., Arthur, A., Mattner, F., Rahardjo, G., Davis, E., Howell, N., Grégoire M. C., Katsifis, A., & Shepherd, R. (2013). Synthesis and biological characterisation of 18 F-SIG343 and 18 F-SIG353, novel and high selectivity σ 2 radiotracers, for tumour imaging properties. EJNMMI Research, 3(1), 80. doi:10.1186/2191-219X-3-80