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Title: Ultraviolet light transmission through the human corneal stroma is reduced in the periphery
Authors: Doutch, JJ
Quantock, AJ
Joyce, NC
Meek, KM
Keywords: Hydration
Issue Date: 21-Mar-2012
Publisher: Cell Press
Citation: Doutch, J. J., Quantock, A. J., Joyce, N. C., Meek, K. M. (2012). Ultraviolet Light Transmission through the Human Corneal Stroma Is Reduced in the Periphery. Biophysical Journal, 102(6), 1258-1264. doi:10.1016/j.bpj.2012.02.023
Abstract: This article investigates in vitro light transmission through the human cornea in the ultraviolet (UV) portion of the electromagnetic spectrum as a function of position across the cornea from center to periphery. Spectrophotometry was used to measure UV transmission in the wavelength range 310-400 nm, from the central cornea to its periphery. UV transmission decreases away from the center, and this is attributed to scattering and absorbance. Corneal endothelial cells, which line the back of the cornea and are more numerous in the periphery, therefore receive a lower dose of UV than do those in the central cornea. This is consistent with the recent observation that endothelial cells in the corneal periphery exhibit less nuclear oxidative DNA damage than those in the central cornea. © 2012, Cell Press.
Gov't Doc #: 4307
ISSN: 0006-3495
Appears in Collections:Journal Articles

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