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Title: Manipulation of polyhydroxybutyrate properties through blending with ethyl-cellulose for a composite biomaterial
Authors: Chan, RTH
Garvey, CJ
Marçal, H
Russell, RA
Holden, PJ
Foster, LJR
Keywords: Films
Composite materials
Issue Date: 30-May-2011
Publisher: Hindawi Publishing Corporation
Citation: Chan, R. T. H., Garvey, C. J., Marcal, H., & Russell, R. A. (2011). Manipulation of polyhydroxybutyrate properties through blending with ethyl-cellulose for a composite biomaterial. International Journal of Polymer Science, 2011, Article ID 651549, 8 pages. doi:10.1155/2011/651549
Abstract: Polyhydroxybutyrate (PHB) is widely used as a biomaterial in medical and tissue-engineering applications, a relatively high crystallinity limits its application. Blending PHB with ethyl-cellulose (EtC) was readily achieved to reduce PHB crystallinity and promote its degradation under physiological conditions without undue influence on biocompatibility. Material strength of composite films remained unchanged at 6.5 ± 0.6 MPa with 40% (w/w) EtC loadings. Phase separation between the two biopolymers was determined with PHB crystallinity decreasing from 63% to 47% for films with the same loading. This reduction in crystallinity supported an increase in the degradation rates of composite films from 0.39 to 0.81% wk−1 for PHB and its composite, respectively. No significant change in morphology and proliferation of olfactory ensheathing cells were observed with the composites despite significant increases in average surface roughness (Ra) of the films from 2.90 to 3.65 μm for PHB and blends with 80% (w/w) EtC, respectively. Copyright © 2011 Rodman T. H. Chan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Gov't Doc #: 3788
ISSN: 1687-9422
Appears in Collections:Journal Articles

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