Manipulation of polyhydroxybutyrate properties through blending with ethyl-cellulose for a composite biomaterial

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dc.contributor.authorChan, RTHen_AU
dc.contributor.authorGarvey, CJen_AU
dc.contributor.authorMarçal, Hen_AU
dc.contributor.authorRussell, RAen_AU
dc.contributor.authorHolden, PJen_AU
dc.contributor.authorFoster, LJRen_AU
dc.date.accessioned2012-02-22T04:29:44Zen_AU
dc.date.available2012-02-22T04:29:44Zen_AU
dc.date.issued2011-05-30en_AU
dc.date.statistics2012-02-22en_AU
dc.description.abstractPolyhydroxybutyrate (PHB) is widely used as a biomaterial in medical and tissue-engineering applications, a relatively high crystallinity limits its application. Blending PHB with ethyl-cellulose (EtC) was readily achieved to reduce PHB crystallinity and promote its degradation under physiological conditions without undue influence on biocompatibility. Material strength of composite films remained unchanged at 6.5 ± 0.6 MPa with 40% (w/w) EtC loadings. Phase separation between the two biopolymers was determined with PHB crystallinity decreasing from 63% to 47% for films with the same loading. This reduction in crystallinity supported an increase in the degradation rates of composite films from 0.39 to 0.81% wk−1 for PHB and its composite, respectively. No significant change in morphology and proliferation of olfactory ensheathing cells were observed with the composites despite significant increases in average surface roughness (Ra) of the films from 2.90 to 3.65 μm for PHB and blends with 80% (w/w) EtC, respectively. Copyright © 2011 Rodman T. H. Chan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_AU
dc.identifier.articlenumber651549en_AU
dc.identifier.citationChan, R. T. H., Garvey, C. J., Marcal, H., & Russell, R. A. (2011). Manipulation of polyhydroxybutyrate properties through blending with ethyl-cellulose for a composite biomaterial. International Journal of Polymer Science, 2011, Article ID 651549, 8 pages. doi:10.1155/2011/651549en_AU
dc.identifier.govdoc3788en_AU
dc.identifier.issn1687-9422en_AU
dc.identifier.issn1687-9430en_AU
dc.identifier.journaltitleInternational Journal of Polymer Scienceen_AU
dc.identifier.pagination8 pagesen_AU
dc.identifier.urihttp://dx.doi.org/10.1155/2011/651549en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/4063en_AU
dc.identifier.volume2011en_AU
dc.language.isoenen_AU
dc.publisherHindawi Publishing Corporationen_AU
dc.subjectFilmsen_AU
dc.subjectMixingen_AU
dc.subjectCompatibilityen_AU
dc.subjectMorphologyen_AU
dc.subjectPhysiologyen_AU
dc.subjectComposite materialsen_AU
dc.titleManipulation of polyhydroxybutyrate properties through blending with ethyl-cellulose for a composite biomaterialen_AU
dc.typeJournal Articleen_AU
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