Alternative chromatographic processes for no-carrier added 177Lu radioisotope separation Part II. The conventional column chromatographic separation combined with HPLC for high purity
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Date
2008-09-01
Journal Title
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Publisher
Springer
Abstract
HPLC technique combined with the simple conventional column solid phase extraction (SPE) chromatography using di-(2-
ethylhexyl)orthophosphoric acid (HDEHP) impregnated OASIS-HLB sorbent based SPE resins (OASIS-HDEHP ) was developed for the
separation of no-carrier added (n.c.a) 177Lu from the bulk quantity of ytterbium target. This combination strategy was based on combining the
advantages of the better resolution of HPLC separation of n.c.a 177Lu from the few milligram level Yb target with the high capacity of the OASISHDEHP
column for the separation of 177Lu from the bulk Yb target. The production batches of several hundred mCi activity of n.c.a 177Lu
radioisotope separated from 50 mg Yb target activated in a nuclear reactor of medium neutron flux (Φ = 5.1013 n.cm–2.s–1) were successfully
performed using this combined separation technique. With the target irradiation in a reactor of higher thermal neutron flux or with the parallel run of several separation units, several Ci-s of n.c.a 177Lu can be profitably produced on a commercial production basis. © 2008, Springer.
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Keywords
Lutetium 177, High-performance liquid chromatography, Radioisotopes, HDEHP, Ytterbium, Neutron flux
Citation
Van So, L., Morcos, N., Zaw, M., Pellegrini, P., Greguric, I., & Nevissi, A., (2008). Alternative chromatographic processes for no-carrier added Lu-177 radioisotope separation - Part II. The conventional column chromatographic separation combined with HPLC for high purity. Journal of Radioanalytical and Nuclear Chemistry, 277(3), 675–683. doi:10.1007/s10967-007-7130-2