Alternative chromatographic processes for no-carrier added 177Lu radioisotope separation Part II. The conventional column chromatographic separation combined with HPLC for high purity

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dc.contributor.authorVan So, Len_AU
dc.contributor.authorMorcos, Nen_AU
dc.contributor.authorZaw, Men_AU
dc.contributor.authorPellegrini, PAen_AU
dc.contributor.authorGreguric, Ien_AU
dc.contributor.authorNevissi, Aen_AU
dc.date.accessioned2011-06-02T04:42:43Zen_AU
dc.date.available2011-06-02T04:42:43Zen_AU
dc.date.issued2008-09-01en_AU
dc.date.statistics2011-06-01en_AU
dc.description.abstractHPLC technique combined with the simple conventional column solid phase extraction (SPE) chromatography using di-(2- ethylhexyl)orthophosphoric acid (HDEHP) impregnated OASIS-HLB sorbent based SPE resins (OASIS-HDEHP ) was developed for the separation of no-carrier added (n.c.a) 177Lu from the bulk quantity of ytterbium target. This combination strategy was based on combining the advantages of the better resolution of HPLC separation of n.c.a 177Lu from the few milligram level Yb target with the high capacity of the OASISHDEHP column for the separation of 177Lu from the bulk Yb target. The production batches of several hundred mCi activity of n.c.a 177Lu radioisotope separated from 50 mg Yb target activated in a nuclear reactor of medium neutron flux (Φ = 5.1013 n.cm–2.s–1) were successfully performed using this combined separation technique. With the target irradiation in a reactor of higher thermal neutron flux or with the parallel run of several separation units, several Ci-s of n.c.a 177Lu can be profitably produced on a commercial production basis. © 2008, Springer.en_AU
dc.identifier.citationVan So, L., Morcos, N., Zaw, M., Pellegrini, P., Greguric, I., & Nevissi, A., (2008). Alternative chromatographic processes for no-carrier added Lu-177 radioisotope separation - Part II. The conventional column chromatographic separation combined with HPLC for high purity. Journal of Radioanalytical and Nuclear Chemistry, 277(3), 675–683. doi:10.1007/s10967-007-7130-2en_AU
dc.identifier.govdoc3383en_AU
dc.identifier.issn0236-5731en_AU
dc.identifier.issue3en_AU
dc.identifier.journaltitleJournal of Radioanalytical and Nuclear Chemistryen_AU
dc.identifier.pagination675–683en_AU
dc.identifier.urihttp://dx.doi.org/10.1007/s10967-007-7130-2en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/3592en_AU
dc.identifier.volume277en_AU
dc.language.isoenen_AU
dc.publisherSpringeren_AU
dc.subjectLutetium 177en_AU
dc.subjectHigh-performance liquid chromatographyen_AU
dc.subjectRadioisotopesen_AU
dc.subjectHDEHPen_AU
dc.subjectYtterbiumen_AU
dc.subjectNeutron fluxen_AU
dc.titleAlternative chromatographic processes for no-carrier added 177Lu radioisotope separation Part II. The conventional column chromatographic separation combined with HPLC for high purityen_AU
dc.typeJournal Articleen_AU
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