Please use this identifier to cite or link to this item: https://apo.ansto.gov.au/dspace/handle/10238/31
Title: High pressure liquid chromatographic assay of technetium in solutions of sodium pertechnetate produced at the AAEC Research Establishment.
Authors: Farrington, KJ
Keywords: Radiopharmaceuticals
Technetium 99
Liquid column chromatography
Sodium compounds
Isotope production
Issue Date: Dec-1985
Publisher: Australian Atomic Energy Commission
Citation: Farrington, K. J. (1985). High pressure liquid chromatographic assay of technetium in solutions of sodium pertechnetate produced at the AAEC Research Establishment. Australian Atomic Energy Commission, Lucas Heights NSW.
Abstract: High pressure liquid chromatography (HPLC) is used for the assay of nanogram quantities of technetium and to determine technetium in decayed pharmaceutical products derived from three methods of manufacture. These methods of manufacture give comparably low levels of technetium-99 at the time of collection of the solution. However when the solutions are used to produce ready-to-inject technetium-99m high levels of technetium-99 are present at the time of calibration which is the day after the collection date. Where sensitive reagent kits are to be labelled freshly collected solutions of technetium-99m should be used. The HPLC assay is a valuable technique for the quality control of technetium-based radiopharmaceuticals and for investigation of methods of manufacture of technetium-99m. Experimental studies confirmed the findings of previous workers.
Gov't Doc #: 962
URI: http://apo.ansto.gov.au/dspace/handle/10238/31
ISBN: 0642598185
Appears in Collections:Scientific and Technical Reports

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