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Title: Measurement of glucose exclusion from the fully hydrated DOPE inverse hexagonal phase.
Authors: Kent, B
Garvey, CJ
Lenné, T
Porcar, L
Garamus, VM
Bryant, G
Keywords: Glucose
Small angle scattering
Phase studies
Crystal structure
Hexagonal lattices
Issue Date: 21-Mar-2010
Publisher: Royal Society of Chemistry
Citation: Kent, B., Garvey, C. J., Lenné, T., Porcar, L., Garamus, V. M., & Bryant, G. (2010). Measurement of glucose exclusion from the fully hydrated DOPE inverse hexagonal phase. Soft Matter, 6(6), 1197-1202. doi:10.1039/b919086d
Abstract: The degree of exclusion of glucose from the inverse hexagonal HII phase of fully hydrated DOPE is determined using contrast variation small angle neutron scattering and small angle X-ray scattering. The presence of glucose is found to favour the formation of the non-lamellar HII phase over the fluid lamellar phase, over a wide range of temperatures, while having no significant effect on the structure of the HII phase. Glucose is preferentially excluded from the lipid–water interface resulting in a glucose concentration in the HII phase of less than half that in the coexisting aqueous phase. The degree of exclusion is quantified and the results are consistent with a hydration layer of pure water adjacent to the lipid head groups from which glucose is excluded. The osmotic gradient created by the difference in glucose concentration is determined and the influence of glucose on the phase behaviour of non-lamellar phase forming lipid systems is discussed. © 2010, Royal Society of Chemistry
Gov't Doc #: 1744
ISSN: 1744-683X
Appears in Collections:Journal Articles

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