Solubility enhancement of aromatic amino acids and peptides in aqueous solution of divalent transition-metal cations - QENS study
International Conference on Neutron Scattering
Generally, the solubility of aromatic amino acids decreases in solution containing multivalent transition-metal ions, such as Cu2+, Pt2+, Pd2+and Co3+, due to the formation of complex precipitates. Surprisingly, we have observed considerably enhanced solubility of tryptophan (Trp) in CuCl2 aqueous solution with a high local concentration of Cu2+ at the surface of Trp [Phys. Rev. Lett. 117, 238102 (2016)]. The solubility increases by 2-5 times that of Trp in pure water. Based on first principle calculations, this unexpected phenomenon is attributed to the strong interaction between Cu2+and the aromatic ring in Trp, referred to as cation–? interaction which modifies the electron distribution of the aromatic ring in Trp and increases the water–aromatic ring interaction.
Transition elements, Solubility, Carboxylic acids, Cations, Copper, Electrons
Yu, D., Shi, G., Mole, R., & Fang, H. (2017). Solubility enhancement of aromatic amino acids and peptides in aqueous solution of divalent transition-metal cations - QENS study. Paper presented at ICNS 2017 (International Conference on Neutron Scattering), Daejeon, South Korea, 9 to 13 July 2017. Retrieved from: http://www.icns2017.org/program.php