Spectroscopic analysis of age-related changes in the brain lateral ventricles during ageing

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dc.contributor.authorHollings, Aen_AU
dc.contributor.authorHackett, MJen_AU
dc.contributor.authorTobin, MJen_AU
dc.contributor.authorKlein, ARen_AU
dc.contributor.authorVongsvivut, JPen_AU
dc.contributor.authorde Jonge, MDen_AU
dc.contributor.authorBone, Sen_AU
dc.contributor.authorWebb, Sen_AU
dc.contributor.authorLam, Ven_AU
dc.contributor.authorTakechi, Ren_AU
dc.contributor.authorMamo, Jen_AU
dc.date.accessioned2023-05-29T04:37:49Zen_AU
dc.date.available2023-05-29T04:37:49Zen_AU
dc.date.issued2021-11-24en_AU
dc.date.statistics2023-04-21en_AU
dc.description.abstractAlzheimer’s disease is the most common form of dementia and poses significant health and economic concerns. Currently, the disease has no cure, and it is expected that over 1 million people could be affected by 2058 in Australia alone. The content and distribution of metals such as Fe, Cu, Zn is known to change in the ageing brain and thus, increased understanding of the mechanistic role of metal dis-homeostasis may illuminate new therapeutic strategies. The brain lateral ventricles, which play a role in controlling metal and ion transport, have shown increasing levels of copper surrounding their walls with ageing. As a redox active metal, copper can induce oxidative stress which is a process that occurs during Alzheimer’s disease onset and progression. Our research group has been interested in determining whether the age-related elevation of copper surrounding the lateral ventricles is inducing oxidative stress in that region. In this study, we have utilised X-Ray Absorption Spectroscopy (XAS) at the Stanford Synchrotron Radiation Lightsource to analyse different chemical forms of sulfur and measure oxidative stress by analysis of disulfides. Additionally, we used the infrared microscopy beamline at the Australian Synchrotron to identify whether any other markers of oxidative stress were present around the ventricles. Further insights into metal dis-homeostasis and its influence on other biochemical pathways, may help to reveal some of the neurochemical mechanisms involved in progression of Alzheimer’s disease. In turn, this may help pave the way for potential preventative or therapeutic models.en_AU
dc.identifier.citationHollings, A., Hackett, M., Tobin, M., Klein, A., Vongsvivut, J., De Jonge, M., Bone, S., Webb, S., Lam, V., Takechi. R., & Mamo, J. (2021). Spectroscopic analysis of age-related changes in the brain lateral ventricles during ageing. Presentation to the ANSTO User Meeting, Online, 24-26 November 2021. Retrieved from: https://events01.synchrotron.org.au/event/146/contributions/4271/contribution.pdfen_AU
dc.identifier.conferenceenddate26 November 2021en_AU
dc.identifier.conferencenameANSTO User Meeting 2021en_AU
dc.identifier.conferenceplaceOnlineen_AU
dc.identifier.conferencestartdate24 November 2021en_AU
dc.identifier.urihttps://events01.synchrotron.org.au/event/146/contributions/4271/contribution.pdfen_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/15044en_AU
dc.language.isoenen_AU
dc.publisherAustralian Nuclear Science and Technology Organisationen_AU
dc.relation.urihttps://events01.synchrotron.org.au/event/146/contributions/4271/contribution.pdfen_AU
dc.subjectSpectroscopyen_AU
dc.subjectAgingen_AU
dc.subjectAge hardeningen_AU
dc.subjectBrainen_AU
dc.subjectDiseasesen_AU
dc.subjectAustraliaen_AU
dc.subjectIronen_AU
dc.subjectCopperen_AU
dc.subjectZincen_AU
dc.titleSpectroscopic analysis of age-related changes in the brain lateral ventricles during ageingen_AU
dc.typeConference Presentationen_AU
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