Hierarchcial structure of solid lipid nanoparticles

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dc.contributor.authorShah, Ren_AU
dc.contributor.authorMata, JPen_AU
dc.contributor.authorBryan, Gen_AU
dc.contributor.authorIfe, Aen_AU
dc.contributor.authorKarpe, Aen_AU
dc.contributor.authorJadhav, Sen_AU
dc.contributor.authorEldridge, Den_AU
dc.contributor.authorPalombo, Een_AU
dc.contributor.authorHarding, Ien_AU
dc.contributor.authorde Campo, Len_AU
dc.date.accessioned2023-12-07T05:29:57Zen_AU
dc.date.available2023-12-07T05:29:57Zen_AU
dc.date.issued2018-11-19en_AU
dc.date.statistics2023-07-06en_AU
dc.description.abstractSuspensions of solid lipid nanoparticles (SLNs) stabilized with emulsifiers have been extensively investigated as drug carriers since the 1990s, although details of their ultrastructure are poorly de fined. Previously, our group reported a novel microwave-assisted microemulsion-based technique Page 22 ANBUG-AINSE Neutron Scattering Symposium, AANSS 2018 / Book of Abstracts to prepare SLNs. Ultrastructure generally relates to interior of the particle and can relate to internal partitioning through, for example, a core-shell structure. It can also relate to the formulation itself, including the particle itself, but can also include structures such as micelles, which may be simultaneously present. Our previous investigations revealed that SLNs were prepared by the novel microemulsion technique have size of 200-300 nm. Preliminary multi-angle SLS/DLS studies indicated core-shell type of SLNs. To understand the detailed ultrastructure of these SLNs, ultra-small angle neutron scattering (USANS) and small angle neutron scattering (SANS) experiments were conducted on suspensions of hydrogenated stearic acid SLNs stabilized with hydrogenated Tween 20 surfactant in D2O. Together, SANS and USANS gave a combined Q range of 4.7 × 10^-5 to 6 × 10^-1 Å^−1 (corresponding to a size range of ~ 1 nm - 15 µm). This extended Q range allows a comprehensive understanding of the hierarchical structure of SLNs. The SANS/USANS data are consistent with the multi-length scale structure of SLNs having polydispersed large particles at the microscale level, intermediate between spheres to rod, with roughened surfaces. At the nanoscale level, the results are consistent with the SLNs solution having an ellipsoidal shape intermediate between spheres and rods, with a crossover from mass fractals to surface fractals. The elucidation of this structure is particularly important given that the structure influences the stability and drug release properties of the nanoparticles. These results will assist in the development of systems with desired shape and properties. © The Authors.en_AU
dc.identifier.citationShah, R., Mata, J., Bryan, G., Ife, A., Karpe, A., Jadhav, S., Eldridge, D., Palombo, E., Harding, I., & de Campo, L. (2018). Hierarchcial structure of solid lipid nanoparticles. Paper presented to the ANBUG-AINSE Neutron Scattering Symposium, AANSS 2018, AINSE Conference Centre New Illawarra Road Lucas Heights NSW 2234, Australia, Monday 19 November 2018 - Wednesday 21 November 2018, (pp. 22-23). Retrieved from https://events01.synchrotron.org.au/event/84/book-of-abstracts.pdfen_AU
dc.identifier.conferenceenddate2018-11-21en_AU
dc.identifier.conferencenameANBUG-AINSE Neutron Scattering Symposium, AANSS 2018en_AU
dc.identifier.conferenceplaceLucas Heights, New South Walesen_AU
dc.identifier.conferencestartdate2018-11-19en_AU
dc.identifier.pagination22-23en_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/15265en_AU
dc.language.isoenen_AU
dc.publisherAustralian Institute of Nuclear Science and Engineering (AINSE)en_AU
dc.relation.urihttps://events01.synchrotron.org.au/event/84/book-of-abstracts.pdfen_AU
dc.subjectNanoparticlesen_AU
dc.subjectEmulsifiersen_AU
dc.subjectNeutronsen_AU
dc.subjectScatteringen_AU
dc.subjectSmall angle scatteringen_AU
dc.subjectSurfacesen_AU
dc.titleHierarchcial structure of solid lipid nanoparticlesen_AU
dc.typeConference Abstracten_AU
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