Histological examination of melanoma xenografts in the nude mouse model: pre and post neutron capture therapy

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dc.contributor.authorCrotty, Ken_AU
dc.contributor.authorMallesch, Jen_AU
dc.contributor.authorMoore, DEen_AU
dc.contributor.authorAllen, BJen_AU
dc.date.accessioned2025-11-24T06:46:56Zen_AU
dc.date.available2025-11-24T06:46:56Zen_AU
dc.date.issued1991-10-02en_AU
dc.date.statistics2025-11-13en_AU
dc.descriptionPhysical copy held by ANSTO Library at DDC: 571.45/15en_AU
dc.description.abstractFollowing the inoculation of 1.5 million Harding Passey melanoma cells in the thigh, subcutaneous (sc) murine melanoma xenografts were grown in the nude mouse model. Mice received 12 mg of enriched boron-10 boronophenylalanine (10BPA ; NCT mice) or no BPA (neutrons only, mice) and the tumours exposed to a neutron fluence of 1013 n cm-2 four hours post ip injection (1). Tumours in the neutrons only mice regressed but all recurred, showing a growth delay of about 3 weeks. However, only 1 of 8 NCT mice showed short term recurrence and 1 of 7 long term recurrence. Three of the NCT mice lived in excess of 300 days before being sacrificed. The irradiated tumour beds showed a dense black mass still visible under the skin but no tumour growth was observed. Sections of the residual NCT tumours, of tumours treated with neutrons only and of untreated tumours were made and stained with haematoxylin and eosin (H&E). No mitoses were observed in the NCT sections, whereas these are evident in all untreated tumours. However, pleomorphic cells were observed in close proximity to capillaries and surrounded by cells with the appearance of histiocytes containing brown pigment. These cells are being examined by other techniques such as electron microscopy to determine whether or not the^ are melanoma cells.en_AU
dc.identifier.booktitle13th AINSE Radiation Biology Conference, 2-4 October 1991, Lucas Heights - AINSE Theatre : conference handbook (programme, abstracts and general information)en_AU
dc.identifier.citationCrotty, K., Mallesch, J., Moore, D. E., & Allen, B. J., (1991). Histological examination of melanoma xenografts in the nude mouse model: pre and post neutron capture therapy. Presentation to the 13th AINSE Radiation Biology Conference, 2-4 October 1991, Lucas Heights - AINSE Theatre : conference handbook (programme, abstracts and general information), (pp. 53). Lucas Heights, New South Wales : AINSE.en_AU
dc.identifier.conferenceenddate1991-10-04en_AU
dc.identifier.conferencename13th AINSE Radiation Biology Conferenceen_AU
dc.identifier.conferenceplaceLucas Heights, New South Walesen_AU
dc.identifier.conferencestartdate1991-10-02en_AU
dc.identifier.pagination53en_AU
dc.identifier.placeofpublicationLucas Heights, New South Walesen_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/16737en_AU
dc.language.isoenen_AU
dc.publisherAINSEen_AU
dc.subjectBiological recoveryen_AU
dc.subjectBoron 10en_AU
dc.subjectExperimental neoplasmsen_AU
dc.subjectHistologyen_AU
dc.subjectMelanomasen_AU
dc.subjectMiceen_AU
dc.subjectNeutron capture therapyen_AU
dc.subjectPost-irradiation examinationen_AU
dc.subjectRadiotherapyen_AU
dc.subjectTherapyen_AU
dc.titleHistological examination of melanoma xenografts in the nude mouse model: pre and post neutron capture therapyen_AU
dc.typeConference Abstracten_AU
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