Mapping the early inflammation process that leads to epilepsy in rodents

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dc.contributor.authorCallaghan, PDen_AU
dc.contributor.authorDedeurwaerdere, Sen_AU
dc.contributor.authorGrégoire, MCen_AU
dc.contributor.authorPham, TQen_AU
dc.contributor.authorKatsifis, Aen_AU
dc.date.accessioned2023-01-24T00:29:22Zen_AU
dc.date.available2023-01-24T00:29:22Zen_AU
dc.date.issued2009-01-09en_AU
dc.date.statistics2022-09-28en_AU
dc.description.abstractImaging of the living brain using Positron Emission Tomography (PET), a noninvasive, sensitive and quantitative imaging methodology, allows us to investigate neurobiological mechanisms involved in the onset of the neurological disease. Our work has focused on investigating the pre-symptomatic neuroinflammatory processes (called epileptogenesis) that lead development of chronic seizures, in an animal model of epilepsy. We have used our in-house radiotracer (18F-PBR111) which is highly specific for receptors expressed in the inflammatory response within the brain. Performing pre-clinical PET imaging with this radioligand allowed us to map and quantify neuroinflammation in vivo, and to correlate this with full in vitro assessment of the neuroinflammation response. The in vivo ligand binding patterns highly correlate with the structures involved in the generation of seizures, and these data reflect the in vitro data, illustrating that the PET binding represents true neuroinflammation. Thus, longitudinal PET studies will be possible in order to follow-up the evolution of the inflammatory regions during the onset of the disease, and test new preventive therapies that modulate this disease process.en_AU
dc.identifier.booktitleResearch selections 2009en_AU
dc.identifier.citationCallaghan, P., Dedeurwaerdere,, S., Gregoire, M., Pham. T., & Katsifis, A. (2009). Mapping the early inflammation process that leads to epilepsy in rodents. In Australian Nuclear Science and Technology Organisation, Research selections 2009. Lucas Heights, NSW: Australian Nuclear Science and Technology Organisation. (pp. 22-25).en_AU
dc.identifier.editorsAustralian Nuclear Science and Technology Organisationen_AU
dc.identifier.pagination22-35en_AU
dc.identifier.placeofpublicationLucas Heights, N. S. W.en_AU
dc.identifier.urihttps://apo.ansto.gov.au/dspace/handle/10238/14473en_AU
dc.language.isoenen_AU
dc.publisherAustralian Nuclear Science and Technology Organisationen_AU
dc.subjectBrainen_AU
dc.subjectImagesen_AU
dc.subjectInflammationen_AU
dc.subjectRodentsen_AU
dc.subjectPositron computed tomographyen_AU
dc.subjectDiseasesen_AU
dc.subjectDataen_AU
dc.subjectTherapyen_AU
dc.titleMapping the early inflammation process that leads to epilepsy in rodentsen_AU
dc.typeBook chapteren_AU
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