Bioaccumulation and biodistribution of selenium in metamorphosing tadpoles

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dc.contributor.authorLanctôt, CMen_AU
dc.contributor.authorCresswell, Ten_AU
dc.contributor.authorCallaghan, PDen_AU
dc.contributor.authorMelvin, SDen_AU
dc.date.accessioned2021-12-10T00:26:55Zen_AU
dc.date.available2021-12-10T00:26:55Zen_AU
dc.date.issued2017-04-19en_AU
dc.date.statistics2021-11-22en_AU
dc.description.abstractSelenium is an important macronutrient with a very narrow margin between essentiality and toxicity. Amphibians are hypothesized to be particularly sensitive due to the potential for metamorphosis-driven mobilization, which could transfer or concentrate contaminant burdens within specific organs. We explored the potential role of tissue degeneration and remodeling during anuran metamorphosis as a mechanism for altering tissue-specific Se burdens. Limnodynastes peronii tadpoles were exposed to dissolved 75Se (as selenite) for 7 days and depurated until completion of metamorphosis. Bioaccumulation and retention kinetics were assessed in whole tadpoles and excised tissues using gamma spectroscopy, and temporal changes in biodistribution were assessed using autoradiography. Tadpoles retained Se throughout metamorphosis, and partitioned the element predominantly within digestive and excretory tissues, including livers > mesonephros > guts > gallbladder. Importantly, our results demonstrate that Se biodistribution varies significantly throughout development. This is indicative of tissue transference, and particularly in tissues developing de novo after depuration. To the best of our knowledge, this is the first study demonstrating Se transference during metamorphic tissue remodelling. Further research is warranted to explore the fate and metabolism of Se (and other metal and metalloids) during anuran development and the implications of transference for influencing toxicity. © 2017 American Chemical Societyen_AU
dc.description.sponsorshipAustralian Institute for Nuclear Science and Engineering Research Award (No. ALNGRA16029)en_AU
dc.identifier.citationLanctôt, C. M., Cresswell, T., Callaghan, P. D., & Melvin, S. D. (2017). Bioaccumulation and biodistribution of selenium in metamorphosing tadpoles. Environmental Science & Technology, 51(10), 5764-5773. doi:10.1021/acs.est.7b00300en_AU
dc.identifier.issn1520-5851en_AU
dc.identifier.issue10en_AU
dc.identifier.journaltitleEnvironmental Science & Technologyen_AU
dc.identifier.pagination5764-5773en_AU
dc.identifier.urihttps://doi.org/10.1021/acs.est.7b00300en_AU
dc.identifier.urihttps://apo.ansto.gov.au/dspace/handle/10238/12423en_AU
dc.identifier.volume51en_AU
dc.language.isoenen_AU
dc.publisherAmerican Chemical Societyen_AU
dc.subjectBiological accumulationen_AU
dc.subjectSeleniumen_AU
dc.subjectAmphibiansen_AU
dc.subjectFrogsen_AU
dc.subjectAnatomyen_AU
dc.subjectCentral nervous systemen_AU
dc.subjectToxicityen_AU
dc.subjectMetamorphosisen_AU
dc.subjectAnimal growthen_AU
dc.titleBioaccumulation and biodistribution of selenium in metamorphosing tadpolesen_AU
dc.typeJournal Articleen_AU
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