Control of neuroinflammation through radiation-induced microglial changes

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dc.contributor.authorBoyd, Aen_AU
dc.contributor.authorByrne, Sen_AU
dc.contributor.authorMiddleton, RJen_AU
dc.contributor.authorBanati, RBen_AU
dc.contributor.authorLiu, GJen_AU
dc.date.accessioned2021-12-16T06:11:23Zen_AU
dc.date.available2021-12-16T06:11:23Zen_AU
dc.date.issued2021-09-10en_AU
dc.date.statistics2021-12-16en_AU
dc.descriptionThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_AU
dc.description.abstractMicroglia, the innate immune cells of the central nervous system, play a pivotal role in the modulation of neuroinflammation. Neuroinflammation has been implicated in many diseases of the CNS, including Alzheimer’s disease and Parkinson’s disease. It is well documented that microglial activation, initiated by a variety of stressors, can trigger a potentially destructive neuroinflammatory response via the release of pro-inflammatory molecules, and reactive oxygen and nitrogen species. However, the potential anti-inflammatory and neuroprotective effects that microglia are also thought to exhibit have been under-investigated. The application of ionising radiation at different doses and dose schedules may reveal novel methods for the control of microglial response to stressors, potentially highlighting avenues for treatment of neuroinflammation associated CNS disorders, such as Alzheimer’s disease and Parkinson’s disease. There remains a need to characterise the response of microglia to radiation, particularly low dose ionising radiation. © The Authors - Open Accessen_AU
dc.identifier.articlenumber2381en_AU
dc.identifier.citationBoyd, A., Byrne, S., Middleton, R. J., Banati, R. B., & Liu, G.-J. (2021). Control of neuroinflammation through radiation-induced microglial changes. Cells, 10(9), 2381. doi:10.3390/cells10092381en_AU
dc.identifier.issn2073-4409en_AU
dc.identifier.issue9en_AU
dc.identifier.journaltitleCellsen_AU
dc.identifier.urihttps://doi.org/10.3390/cells10092381en_AU
dc.identifier.urihttps://apo.ansto.gov.au/dspace/handle/10238/12500en_AU
dc.identifier.volume10en_AU
dc.language.isoenen_AU
dc.publisherMDPIen_AU
dc.subjectInflammationen_AU
dc.subjectMitochondriaen_AU
dc.subjectCell constituentsen_AU
dc.subjectLymphokinesen_AU
dc.subjectAntioxidantsen_AU
dc.subjectCentral nervous systemen_AU
dc.subjectDiseasesen_AU
dc.subjectLow dose irradiationen_AU
dc.titleControl of neuroinflammation through radiation-induced microglial changesen_AU
dc.typeJournal Articleen_AU
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