Synthesis of perdeuterated and selectively deuterated phospholipids and lipids for neutron applications

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dc.contributor.authorYepuri, NRen_AU
dc.contributor.authorDarwish, TAen_AU
dc.contributor.authorKrause-Heuer, AMen_AU
dc.contributor.authorLeung, Aen_AU
dc.contributor.authorCagnes, MPen_AU
dc.contributor.authorHolden, PJen_AU
dc.date.accessioned2021-10-27T22:29:55Zen_AU
dc.date.available2021-10-27T22:29:55Zen_AU
dc.date.issued2016-11-29en_AU
dc.date.statistics2021-10-17en_AU
dc.description.abstractThe National Deuteration Facility (NDF) is focused on the provision of deuterated molecules which extends the options for contrast in neutron scattering to encompass not only solvent but molecular deuteration. Over the past few years the NDF has expanded its synthesis capability from simple deuterated fatty acids to complex deuterated molecules including lipids and phospholipids. We are now able to produce head or tail deuterated lipids including phospholipids based on oleic acid with a range of head groups (Fig. 1). These include perdeuterated 1,2-oleoyl-sn-glycero-3-phosphocholine (POPC), selectively deuterated POPC, branched chain (phytanic) phospholipids 1,2-diphytanoyl-sn-glycero-3-phosphocholine (DPhyPC), and perdeuterated mono oleoyl glycerol and phytanoyl monoethanolamide.[1] These lipids have been extensively used in constructing biologically more relevant model membranes and lipidic matrices for investigations using neutron studies. These include structural and dynamical studies of biomimetic membranes and the encapsulation of biomolecules in lipid-based bicontinuous cubic phases for drug-delivery, membrane protein crystallization, and biosensor applications. Details about design, synthesis and characterisation of these deuterated precursors and final compound will be presented.en_AU
dc.identifier.citationYepuri, N. R., Darwish, T. A., Krause-Heuer, A., Leung, A., Cagnes, M., & Holden, P. J. (2016). Synthesis of perdeuterated and selectively deuterated phospholipids and lipids for neutron applications. Paper presented at 13th AINSE-ANBUG Neutron Scattering Symposium, Sydney, NSW, Australia, 29-30 November 2016.en_AU
dc.identifier.conferenceenddate30 November 2016en_AU
dc.identifier.conferencename13th AINSE-ANBUG Neutron Scattering Symposiumen_AU
dc.identifier.conferenceplaceSydney, NSW, Australiaen_AU
dc.identifier.conferencestartdate29 November 2016en_AU
dc.identifier.urihttps://apo.ansto.gov.au/dspace/handle/10238/12142en_AU
dc.language.isoenen_AU
dc.publisherAustralian Institute of Nuclear Science and Engineeringen_AU
dc.subjectDeuterationen_AU
dc.subjectLipidsen_AU
dc.subjectPhospholipidsen_AU
dc.subjectScatteringen_AU
dc.subjectOleic aciden_AU
dc.subjectEncapsulationen_AU
dc.titleSynthesis of perdeuterated and selectively deuterated phospholipids and lipids for neutron applicationsen_AU
dc.typeConference Abstracten_AU
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