A general and efficient synthesis of 5,6-dihydrodibenzo[b,h][1,6]naphthyridine derivatives

Dobrowolski, JC; Katen, A; Fraser, BH; Bhadbhade, MM; Black, DS; Kumar, N

A general and efficient synthesis of 5,6-dihydrodibenzo[b,h][1,6]naphthyridine derivatives

Date

2016-12-07

Authors

Publisher

Elsevier B. V.

Abstract

A two-step procedure for the synthesis of dihydrodibenzonaphthyridine derivatives from benzaldehydes and 2-aminoacetophenones, proceeding through a substituted dihydroquinolone intermediate, is described. The synthetic protocol allows for a versatile and robust coupling method between a range of 2-aminoacetophenones or 2-aminobenzophenones and a selection of substituted dihydroquinolones. © 2016 Elsevier B.V.

Keywords

Synthesis, Derivatization, Chemical reactions, Benzaldehyde, Flavonoids, Malaria, Nitrogen

Citation

Dobrowolski, J. C., Katen, A., Fraser, B. H., Bhadbhade, M., Black, D. S., & Kumar, N. (2016). A general and efficient synthesis of 5,6-dihydrodibenzo[b,h][1,6]naphthyridine derivatives. Tetrahedron Letters, 57(49), 5442-5445. doi:10.1016/j.tetlet.2016.10.067