Tissue disposition of 26aluminum in rats measured by accelerator mass spectrometry

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dc.contributor.authorWalker, VRen_AU
dc.contributor.authorSutton, RAen_AU
dc.contributor.authorMeirav, Oen_AU
dc.contributor.authorSossi, Ven_AU
dc.contributor.authorJohnson, Ren_AU
dc.contributor.authorKlein, Jen_AU
dc.contributor.authorFink, Den_AU
dc.contributor.authorMiddleton, RJen_AU
dc.date.accessioned2021-12-08T01:17:28Zen_AU
dc.date.available2021-12-08T01:17:28Zen_AU
dc.date.issued1994-10en_AU
dc.date.statistics2021-10-19en_AU
dc.description.abstractA trace quantity of 26aluminum (26Al) was administered intravenously to 1 normal and 1 uremic rat. After a 3-week period, the animals were sacrificed and samples of bone, muscle, kidney, liver, heart, and brain were analyzed for their 26Al content. In the normal and uremic rats, most of the tissue 26Al was found in bone amounting to 0.9% and 2.0%, respectively, of administered dose/g dry weight of tissue. Much smaller amounts of isotope were found in the other tissues in both animals. In the normal rat, the descending order of 26Al content in other tissues was: kidney, 0.2% > liver, 0.06% > heart, 0.03%, > brain and muscle, 0.02%. In the uremic rat, the same order of tissue 26Al content was found with kidney, 0.37% > liver, 0.06% > heart, 0.02% > brain and muscle, 0.01% per g dry weight of tissue. When expressed per g wet weight of tissue in the 2 animals, a similar order of tissue 26Al content was found. In comparing the amount of 26Al in the bone of the 2 rats, the uremic animal was found to have more than twice that found in the bone of the normal rat when expressed either per g dry or wet weight of bone. However, 26Al content of other tissues was similar in the 2 animals. This suggests that uremic bone may have a greater affinity for aluminum than normal bone, but kidney, liver, brain, heart, and muscle appear to behave similarly in uremic and normal rats in regard to incorporation of a single trace dose of isotope in the 3-week time frame of the present study.en_AU
dc.identifier.citationWalker. V. R., Sutton, R. A., Meirav, O., Sossi, V., Johnson, R., Klein, J., Fink, D., & Middleton, R. (1994). Tissue disposition of 26aluminum in rats measured by accelerator mass spectrometry. Clinical and Investigative Medicine, 17(5), 420-425.en_AU
dc.identifier.issn0147-958Xen_AU
dc.identifier.issue5en_AU
dc.identifier.journaltitleClinical and Investigative Medicineen_AU
dc.identifier.pagination420-425en_AU
dc.identifier.urihttps://apo.ansto.gov.au/dspace/handle/10238/12387en_AU
dc.identifier.volume17en_AU
dc.language.isoenen_AU
dc.publisherCanadian Society for Clinical Investigationen_AU
dc.subjectRatsen_AU
dc.subjectAnimal tissuesen_AU
dc.subjectIsotopesen_AU
dc.subjectTrace amountsen_AU
dc.subjectDose ratesen_AU
dc.subjectAluminiumen_AU
dc.titleTissue disposition of 26aluminum in rats measured by accelerator mass spectrometryen_AU
dc.typeJournal Articleen_AU
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