The impact of pH on packing in tethered lipid bilayers

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dc.contributor.authorCranfield, CGen_AU
dc.contributor.authorBerry, Ten_AU
dc.contributor.authorHolt, SAen_AU
dc.contributor.authorLe Brun, APen_AU
dc.contributor.authorValenzuela, SMen_AU
dc.contributor.authorCoster, HGLen_AU
dc.contributor.authorCornell, BAen_AU
dc.date.accessioned2021-10-26T21:32:22Zen_AU
dc.date.available2021-10-26T21:32:22Zen_AU
dc.date.issued2016-11-29en_AU
dc.date.statistics2021-10-11en_AU
dc.description.abstractWe report that increasing the H3O+ concentration when lowering the pH reduces the intrinsic ionic conduction through phospholipid bilayers (Fig 1A), which is counter to what might be expected from increasing the H3O+ concentration. We attribute the conduction decrease to a reduction of the molecular area per lipid (ao)[1]. These effects are seen at H3O+ concentrations in the range nM to µM despite these being very low concentrations compared to that of a typical bathing electrolyte solution of 135mM ionic concentration. We present a model, in which the pH dependent reduction in ao favours an increase in lipid packing. To support this model, we provide evidence of the effects of the hydronium ion on lipid geometry using neutron reflectometry (Fig 1C). Further examples will be given of the impact of the H3O ion concentration on the hydrogen bonding within the polar groups of lipid.en_AU
dc.identifier.citationCranfield, C. G., Berry, T., Holt, S. A., Le Brun, A. P., Valenzuela, S. M., Coster, H., & Cornell, B. (2016). The impact of pH on packing in tethered lipid bilayers. Paper presented at 13th AINSE-ANBUG Neutron Scattering Symposium, Sydney, NSW, Australia, 29-30 November 2016.en_AU
dc.identifier.conferenceenddate30 November 2016en_AU
dc.identifier.conferencename13th AINSE-ANBUG Neutron Scattering Symposiumen_AU
dc.identifier.conferenceplaceSydney, NSW, Australiaen_AU
dc.identifier.conferencestartdate29 November 2016en_AU
dc.identifier.urihttps://apo.ansto.gov.au/dspace/handle/10238/12096en_AU
dc.language.isoenen_AU
dc.publisherAustralian Institute of Nuclear Science and Engineeringen_AU
dc.subjectLipidsen_AU
dc.subjectIonic conductivityen_AU
dc.subjectPhospholipidsen_AU
dc.subjectElectrolytesen_AU
dc.subjectOxonium ionsen_AU
dc.subjectHydrogenen_AU
dc.titleThe impact of pH on packing in tethered lipid bilayersen_AU
dc.typeConference Abstracten_AU
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