Study of titania modified porous alumina membranes for protein transport and separation
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Date
2011-09-18
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Engineers Australia
Abstract
The use of nanoporous membranes in molecular separation or sieving, which involve the separation of molecular mixtures, is gaining rapid interest. The ability to modify and alter their pore size and dimensions, along with the physical and chemical properties of the material that constitute these pores make them highly sensitive to such applications, particularly protein separation. Our study investigated the use of titania modified porous anodic alumina (AAO) membranes. Titania was deposited using atomic layer deposition (ALD) for different number of cycles in order to generate membranes with reduced poresizes ranging from 100nm-10nm. Protein permeation experiments using bovine serum albumin (BSA) and Lysozyme (Lys) were conducted to show selectivity in transport and separation of the proteins. Transport occurred by diffusion and a subsequent decrease in flow rate was observed with decrease in pore size of the membranes. In addition, the use of titania modified AAO membranes demonstrated minimal extent of non-specific absorption of proteins along the pores during permeation when subject to UV radiation. The resultant titania coated AAO membranes achieved controlled reduction of pore size using ALD and are thus, applicable for advanced protein transport, separation and catalysis. © 2011 Engineers Australia
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Keywords
Proteins, Membrane transport, Membranes, Aluminium oxides, Titanium, Porosity, Layers
Citation
Nambiar, M., Evans, P. J., Triani, G., Shapter, J. G., & Losic, D. (2011). Study of titania modified porous alumina membranes for protein transport and separation. Paper presented at Chemeca 2011: Engineering a Better World, Sydney Hilton Hotel, Sydney, NSW, Australia, 18-21 September 2011. In Chemeca 2011: Engineering a Better World: Sydney Hilton Hotel, NSW, Australia, 18-21 September 2011, (pp. 2863-2867). Barton, ACT: Engineers Australia. Retrieved from: https://search.informit.org/doi/abs/10.3316/INFORMIT.194145169744196