QCM-D and neutron reflectometry study of effect of plasma treatment on cellulose-mucin interactions towards ETSA

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dc.contributor.authorSiddique, Aen_AU
dc.contributor.authorGresham, IJen_AU
dc.contributor.authorDavies, Jen_AU
dc.contributor.authorOng, Hen_AU
dc.contributor.authorTraini, Den_AU
dc.contributor.authorNelson, Aen_AU
dc.contributor.authorSpicer, Pen_AU
dc.contributor.authorPrescott, SWen_AU
dc.date.accessioned2023-05-05T05:04:34Zen_AU
dc.date.available2023-05-05T05:04:34Zen_AU
dc.date.issued2020-11-11en_AU
dc.date.statistics2023-05-04en_AU
dc.description.abstractEpidemic thunderstorm asthma (ETSA)[1] is associated with inhalation of airborne pollen grains and aerosolized pollen fragments, causing hypersensitive immune reactions[2] that might lead to an asthma attack. The wall of pollen grains (intine) contains cellulose which is hypothesized to initially interact with the nasal and tracheal mucous layer[3] when inhaled. The air-way mucous layer is comprised of mucin (a major glycosylated proteinaceous element) and water, which serves as a first-line-of-defence against inhaled pollen particles. Although immunological and meteorological studies have been conducted in this regard, the fundamental cause and mechanism of ETSA are under-investigated. This study is focused on unraveling inherent cellulose-mucin interactions employing quartz crystal microbalance with dissipation (QCM-D) and neutron reflectometry (NR) examining the adsorption of mucin on cellulose while mimicking a thunderstorm environment, such as the affect of plasma treatment on cellulose-mucin interactions. Here, we generate air-plasma and plasma-activated water to treat our model cellulose surfaces[4], simulating the ionized surface chemistry of thunderstorm-borne pollen particles and examine subsequent interactions. In this poster, we describe the use of QCM-D and NR to investigate cellulose-mucin interactions and the effect of plasma treatment on these biointerfacial interactions. The advanced molecular and structural data obtained from this study, coupled with immunological and meteorological investigations, will enable the mechanistic understanding, treatment, and prevention of ETSA. © The authors.en_AU
dc.identifier.citationSiddique, A., Gresham, I., Davies, J., Ong, H., Traini, D., Nelson, A., Spicer, P., & Prescott, S. (2020). QCM-D and neutron reflectometry study of effect of plasma treatment on cellulose-mucin interactions towards ETSA. Paper presented to the ANBUG-AINSE Neutron Scattering Symposium, AANSS 2020, Virtual Meeting, 11th - 13th November 2020, (pp. 110). Retrieved from: https://events01.synchrotron.org.au/event/125/attachments/725/1149/AANSS_Abstract_Booklet_Complete_-_1_Page_Reduced.pdfen_AU
dc.identifier.conferenceenddate13 November 2020en_AU
dc.identifier.conferencenameANBUG-AINSE Neutron Scattering Symposium, AANSS 2020en_AU
dc.identifier.conferenceplaceVirtual Meetingen_AU
dc.identifier.conferencestartdate11 November 2020en_AU
dc.identifier.pagination110en_AU
dc.identifier.urihttps://events01.synchrotron.org.au/event/125/contributions/3693/contribution.pdfen_AU
dc.identifier.urihttps://apo.ansto.gov.au/dspace/handle/10238/15023en_AU
dc.language.isoenen_AU
dc.publisherAustralian Institute of Nuclear Science and Engineering (AINSE)en_AU
dc.subjectInhalationen_AU
dc.subjectImmune reactionsen_AU
dc.subjectPollenen_AU
dc.subjectCelluloseen_AU
dc.subjectHypothesisen_AU
dc.subjectPlasmaen_AU
dc.subjectTherapyen_AU
dc.subjectCrystalsen_AU
dc.subjectNeutronsen_AU
dc.subjectMoleculesen_AU
dc.titleQCM-D and neutron reflectometry study of effect of plasma treatment on cellulose-mucin interactions towards ETSAen_AU
dc.typeConference Abstracten_AU
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