Cytotoxicity and structural analyses of 2,2′‐bipyridine‐, 4,4′‐dimethyl‐2,2′‐bipyr­idine‐ and 2‐(2′‐pyridyl)quinoxalineplatinum(II) complexes

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dc.contributor.authorPages, BJen_AU
dc.contributor.authorZhang, YJen_AU
dc.contributor.authorLi, Fen_AU
dc.contributor.authorSakoff, Jen_AU
dc.contributor.authorGilbert, Jen_AU
dc.contributor.authorAldrich-Wright, JRen_AU
dc.date.accessioned2020-03-27T03:40:56Zen_AU
dc.date.available2020-03-27T03:40:56Zen_AU
dc.date.issued2015-08-07en_AU
dc.date.statistics2020-03-20en_AU
dc.description.abstractPlatinum anticancer complexes incorporating 2,2′-bipyridine (bpy), 4,4′-dimethyl-2,2′-bipyridine (44Me2bpy) or 2-(2′-pyridyl)quinoxaline (2pq) as polyaromatic ligands and the S,S or R,R isomer of 1,2-diaminocyclohexane as ancillary ligands in the form [Pt(PL)(AL)]2+ have been synthesised and characterised. X-ray diffraction was used to elucidate the structure and stacking behaviour of the complexes, revealing interesting properties that may impact their biological activity. Pulsed gradient spin-echo NMR experiments elucidated the aggregation behaviour of these complexes in solution. The cytotoxicity of each complex was assessed against the L1210 murine leukaemia, HT29 human colon carcinoma and U87 human glioblastoma cell lines and compared to other complexes within this class. The complexes incorporating 44Me2bpy were found to be the most potent at inhibiting cell growth with IC50 values for the S,S isomer (0.13–0.5 μM) less than that for cisplatin (0.36–11 μM), oxaliplatin (0.9–1.8 μM) or carboplatin (>50 μM). Most complexes were found to be very effective against HT29 colon carcinoma cells. © 1999-2020 John Wiley & Sons, Inc.en_AU
dc.identifier.citationZhang, Y., Li, F., Sakoff, J., Gilbert, J., & Aldrich‐Wright, J. R. (2015). Cytotoxicity and structural analyses of 2, 2′‐bipyridine‐, 4, 4′‐dimethyl‐2, 2′‐bipyridine‐and 2‐(2′‐pyridyl) quinoxalineplatinum (II) complexes. European Journal of Inorganic Chemistry, 2015(25), 4167-4175. doi.:10.1002/ejic.201500754en_AU
dc.identifier.govdoc9080en_AU
dc.identifier.issn0368-2471en_AU
dc.identifier.issue25en_AU
dc.identifier.journaltitleEuropean Journal of Inorganic Chemistryen_AU
dc.identifier.pagination4167-4175en_AU
dc.identifier.urihttps://doi.org/10.1002/ejic.201500754en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/9272en_AU
dc.identifier.volume2015en_AU
dc.language.isoenen_AU
dc.publisherJohn Wiley and Sonsen_AU
dc.subjectLigandsen_AU
dc.subjectNeoplasmsen_AU
dc.subjectLeukemiaen_AU
dc.subjectLarge intestineen_AU
dc.subjectCrystallographyen_AU
dc.subjectX-ray diffractionen_AU
dc.subjectSynthesisen_AU
dc.subjectComplexesen_AU
dc.titleCytotoxicity and structural analyses of 2,2′‐bipyridine‐, 4,4′‐dimethyl‐2,2′‐bipyr­idine‐ and 2‐(2′‐pyridyl)quinoxalineplatinum(II) complexesen_AU
dc.typeJournal Articleen_AU
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