Thermal denaturation of A-DNA

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dc.contributor.authorValle-Orero, Jen_AU
dc.contributor.authorWildes, ARen_AU
dc.contributor.authorTheodorakopoulos, Nen_AU
dc.contributor.authorCuesta-López, Sen_AU
dc.contributor.authorGarden, JLen_AU
dc.contributor.authorDanilkin, SAen_AU
dc.contributor.authorPeyrard, Men_AU
dc.date.accessioned2016-12-05T23:04:58Zen_AU
dc.date.available2016-12-05T23:04:58Zen_AU
dc.date.issued2014-11-07en_AU
dc.date.statistics2016-12-06en_AU
dc.description.abstractThe DNA molecule can take various conformational forms. Investigations focus mainly on the so-called 'B-form', schematically drawn in the famous paper by Watson and Crick [1]. This is the usual form of DNA in a biological environment and is the only form that is stable in an aqueous environment. Other forms, however, can teach us much about DNA. They have the same nucleotide base pairs for 'building blocks' as B-DNA, but with different relative positions, and studying these forms gives insight into the interactions between elements under conditions far from equilibrium in the B-form. Studying the thermal denaturation is particularly interesting because it provides a direct probe of those interactions which control the growth of the fluctuations when the 'melting' temperature is approached. Here we report such a study on the 'A-form' using calorimetry and neutron scattering. We show that it can be carried further than a similar study on B-DNA, requiring the improvement of thermodynamic models for DNA.© 2014 IOP Publishing Ltd and Deutsche Physikalische Gesellschaft.en_AU
dc.identifier.articlenumber113017en_AU
dc.identifier.citationValle-Orero, J., Wildes, A. R., Theodorakopoulos, N., Cuesta-López, S., Garden, J. L., Danilkin, S., & Peyrard, M. (2014). Thermal denaturation of A-DNA. New Journal of Physics, 16, 113017. doi:10.1088/1367-2630/16/11/113017en_AU
dc.identifier.govdoc7661en_AU
dc.identifier.issn1367-2630en_AU
dc.identifier.journaltitleNew Journal of Physicsen_AU
dc.identifier.urihttp://dx.doi.org/10.1088/1367-2630/16/11/113017en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/8117en_AU
dc.identifier.volume16en_AU
dc.language.isoenen_AU
dc.publisherIOP Scienceen_AU
dc.subjectDNAen_AU
dc.subjectMoleculesen_AU
dc.subjectAqueous solutionsen_AU
dc.subjectNeutronsen_AU
dc.subjectThermodynamic activityen_AU
dc.subjectThermal analysisen_AU
dc.titleThermal denaturation of A-DNAen_AU
dc.typeJournal Articleen_AU
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