Investigating the binding properties of porous drug delivery systems using nuclear sensors (radiotracers) and positron annihilation lifetime spectroscopy – predicting conditions for optimum performance

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dc.contributor.authorMume, Een_AU
dc.contributor.authorLynch, DEen_AU
dc.contributor.authorUedono, Aen_AU
dc.contributor.authorSmith, SVen_AU
dc.date.accessioned2013-11-27T03:54:41Zen_AU
dc.date.available2013-11-27T03:54:41Zen_AU
dc.date.issued2011-01-01en_AU
dc.date.statistics2013-11-27en_AU
dc.description.abstractUnderstanding how the size, charge and number of available pores in porous material influences the uptake and release properties is important for optimising their design and ultimately their application. Unfortunately there are no standard methods for screening porous materials in solution and therefore formulations must be developed for each encapsulated agent. This study investigates the potential of a library of radiotracers (nuclear sensors) for assessing the binding properties of hollow silica shell materials. Uptake and release of Cu2+ and Co2+ and their respective complexes with polyazacarboxylate macrocycles (dota and teta) and a series of hexa aza cages (diamsar, sarar and bis-(p-aminobenzyl)-diamsar) from the hollow silica shells was monitored using their radioisotopic analogues. Coordination chemistry of the metal (M) species, subtle alterations in the molecular architecture of ligands (Ligand) and their resultant complexes (M-Ligand) were found to significantly influence their uptake over pH 3 to 9 at room temperature. Positively charged species were selectively and rapidly (within 10 min) absorbed at pH 7 to 9. Negatively charged species were preferentially absorbed at low pH (3 to 5). Rates of release varied for each nuclear sensor, and time to establish equilibrium varied from minutes to days. The subtle changes in design of the nuclear sensors proved to be a valuable tool for determining the binding properties of porous materials. The data support the development of a library of nuclear sensors for screening porous materials for use in optimising the design of porous materials and the potential of nuclear sensors for high through-put screening of materials. © 2011, Royal Society of Chemistryen_AU
dc.description.sponsorshipWe thank Australian Research Council funding for the ARC Centre of Excellence for Antimatter-Matter Studiesen_AU
dc.identifier.citationMume, E., Lynch, D. E., Uedono, A., & Smith, S. V. (2013). Investigating the binding properties of porous drug delivery systems using nuclear sensors (radiotracers) and positron annihilation lifetime spectroscopy – predicting conditions for optimum performance. Dalton Transactions, 40 (23), 6278-6288. doi:10.1039/c0dt01499ken_AU
dc.identifier.govdoc5295en_AU
dc.identifier.issn1477-9226en_AU
dc.identifier.issue23en_AU
dc.identifier.journaltitleDalton Transactionsen_AU
dc.identifier.pagination6278-6288en_AU
dc.identifier.urihttp://dx.doi.org/10.1039/c0dt01499ken_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/5037en_AU
dc.identifier.volume40en_AU
dc.language.isoenen_AU
dc.publisherRoyal Society Chemistryen_AU
dc.subjectPorosityen_AU
dc.subjectSilicaen_AU
dc.subjectSensorsen_AU
dc.subjectLigandsen_AU
dc.subjectDrugsen_AU
dc.subjectPerformanceen_AU
dc.titleInvestigating the binding properties of porous drug delivery systems using nuclear sensors (radiotracers) and positron annihilation lifetime spectroscopy – predicting conditions for optimum performanceen_AU
dc.typeJournal Articleen_AU
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