Teasaponin reduces inflammation and central leptin resistance in diet-induced obese male mice

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dc.contributor.authorYu, YHen_AU
dc.contributor.authorWu, YZen_AU
dc.contributor.authorWu, ZXen_AU
dc.contributor.authorWang, HQen_AU
dc.contributor.authorLi, Den_AU
dc.contributor.authorHuang, XFen_AU
dc.date.accessioned2020-03-24T22:33:41Zen_AU
dc.date.available2020-03-24T22:33:41Zen_AU
dc.date.issued2013-09-01en_AU
dc.date.statistics2020-03-20en_AU
dc.description.abstractChronic inflammation is involved in the pathogenesis of obesity and type 2 diabetes. Recently teasaponin, an extract from tea, has been shown to have antiinflammatory effects. We examined the effect of teasaponin on obesity, inflammation, glucose metabolism, and central leptin sensitivity in obese mice fed a high-fat (HF) diet for 16 weeks. Intraperitoneal injections of teasaponin (10 mg/kg, daily) for 21 days significantly decreased the food intake and body weight of HF diet-induced obese mice. Teasaponin treatment also reduced the protein levels of proinflammatory cytokines (TNF-α, IL-6, and/or IL-1β) and nuclear factor-κB signaling (phosphorylated inhibitory-κB kinase and phosphorylated inhibitory-κBα) in adipose tissue and the liver. The antiinflammatory effects of teasaponin were associated with improved glycemic status in the treated animals, evidenced by improved glucose tolerance, homeostasis model assessment, and fasting plasma insulin. In the hypothalamus, teasaponin decreased both proinflammatory cytokines and inflammatory signaling in the mediobasal hypothalamus. Teasaponin treatment also enhanced the anorexigenic effect of central leptin administration, restored leptin phosphorylated signal transducer and activator of transcription-3 (p-STAT3) signaling in the arcuate nucleus, and increased hypothalamic expression of the anorexigenic peptide proopiomelanocortin. These results identify a potential novel application for teasaponin as an antiobesity and antiinflammatory agent. © 2013, Oxford University Pressen_AU
dc.identifier.citationYu, Y., Wu, Y., Szabo, A., Wu, Z., Wang, H., Li, D., & Huang, X. F. (2013). Teasaponin reduces inflammation and central leptin resistance in diet-induced obese male mice. Endocrinology, 154(9), 3130-3140. doi:10.1210/en.2013-1218en_AU
dc.identifier.govdoc8909en_AU
dc.identifier.issn1945-7170en_AU
dc.identifier.issue9en_AU
dc.identifier.journaltitleEndocrinologyen_AU
dc.identifier.pagination3130-3140en_AU
dc.identifier.urihttps://doi.org/10.1210/en.2013-1218en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/9228en_AU
dc.identifier.volume154en_AU
dc.language.isoenen_AU
dc.publisherOxford University Pressen_AU
dc.subjectLeptinen_AU
dc.subjectMiceen_AU
dc.subjectDieten_AU
dc.subjectBeveragesen_AU
dc.subjectInflammationen_AU
dc.subjectDiabetes mellitusen_AU
dc.subjectGlucoseen_AU
dc.subjectMetabolismen_AU
dc.subjectPlasmaen_AU
dc.subjectInsulinen_AU
dc.titleTeasaponin reduces inflammation and central leptin resistance in diet-induced obese male miceen_AU
dc.typeJournal Articleen_AU
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