DHA prevents altered 5-HT1A, 5-HT2A, CB1 and GABAA receptor binding densities in the brain of male rats fed a high-saturated-fat diet

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dc.contributor.authorYu, YHen_AU
dc.contributor.authorWu, YZen_AU
dc.contributor.authorPatch, Cen_AU
dc.contributor.authorWu, ZXen_AU
dc.contributor.authorSzabo, Aen_AU
dc.contributor.authorLi, Den_AU
dc.contributor.authorHuang, XFen_AU
dc.date.accessioned2019-11-12T04:07:26Zen_AU
dc.date.available2019-11-12T04:07:26Zen_AU
dc.date.issued2013-07-01en_AU
dc.date.statistics2019-11-12en_AU
dc.description.abstractLow levels of docosahexaenoic acid (DHA) have been linked to a number of mental illnesses such as memory loss, depression and schizophrenia. While supplementation of DHA is beneficial in improving memory and cognition, the influence of dietary fats on the neurotransmitters and receptors involved in cognitive function is still not known. The aim of this study was to investigate serotonin receptor (5-HT(1A) and 5-HT2A), cannabinoid receptor (CB1) and gamma-aminobutyric acid type A (GABA(A)) receptor binding densities in the brain of male rats fed a high-saturated-fat (HF) diet, as well as the effect of DHA supplementation on HF diet. Alterations of these receptors in the post-mortem rat brain were detected by [(3)H]-WAY-100635, [(3)H]-ketanserin, [(3)H]-CP-55,940 and [(3)H]-muscimol binding autoradiography, respectively. In the hippocampus, the 5-HT(1A), CB1 and GABA(A) receptor binding densities significantly increased in response to an HF diet, while in the hypothalamus, 5-HT(1A) and CB1 binding densities significantly increased in HF-fed rats. Importantly, DHA supplementation prevented the HF-induced increase of receptors binding density in the hippocampus and hypothalamus. Furthermore, DHA supplementation attenuated 5-HT2A receptor binding density in the caudate putamen, anterior cingulate cortex and medial mammillary nucleus, which was also increased in HF group. This study showed that an HF diet increased 5-HT(1A), 5-HT2A, CB1 and GABA(A) receptor binding densities in the brain regions involved in cognitive function and that dietary DHA can attenuate such alterations. These findings provide insight into the mechanism by which DHA supplementation ameliorates reduced cognitive function associated with an HF diet. © 2013 Elsevier Inc.en_AU
dc.identifier.citationYu, Y., Wu, Y., Patch, C., Wu, Z., Szabo, A., Li, D., & Huang, X. F. (2013). DHA prevents altered 5-HT1 A, 5-HT2 A, CB1 and GABA A receptor binding densities in the brain of male rats fed a high-saturated-fat diet. The Journal of Nutritional Biochemistry, 24(7), 1349-1358. doi:10.1016/j.jnutbio.2012.11.002en_AU
dc.identifier.govdoc8908en_AU
dc.identifier.issn0955-2863en_AU
dc.identifier.issue7en_AU
dc.identifier.journaltitleThe Journal of Nutritional Biochemistryen_AU
dc.identifier.pagination1349-1358en_AU
dc.identifier.urihttps://doi.org/10.1016/j.jnutbio.2012.11.002en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/9087en_AU
dc.identifier.volume24en_AU
dc.language.isoenen_AU
dc.publisherElsevieren_AU
dc.subjectSerotoninen_AU
dc.subjectReceptorsen_AU
dc.subjectPharmacologyen_AU
dc.subjectMental disordersen_AU
dc.subjectHypothalamusen_AU
dc.subjectHippocampusen_AU
dc.subjectDieten_AU
dc.subjectFatsen_AU
dc.titleDHA prevents altered 5-HT1A, 5-HT2A, CB1 and GABAA receptor binding densities in the brain of male rats fed a high-saturated-fat dieten_AU
dc.typeJournal Articleen_AU
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