Optimisation of [11C]raclopride production using a synthra GPextent system

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dc.contributor.authorPerkins, Gen_AU
dc.contributor.authorSheth, Ren_AU
dc.contributor.authorGreguric, Ien_AU
dc.contributor.authorPascali, Gen_AU
dc.date.accessioned2020-03-29T21:52:44Zen_AU
dc.date.available2020-03-29T21:52:44Zen_AU
dc.date.issued2014-12-01en_AU
dc.date.statistics2020-03-20en_AU
dc.description.abstractThe dopamine D2 receptor radiotracer [(11)C]Raclopride is used extensively in clinical and preclinical imaging. Currently, a wide range of methods to produce [(11)C]Raclopride have been developed using traditional vessel reactions as well as cartridge or captive solvent. This work reports the optimisation of the production of [(11)C]Raclopride using a Synthra GPextent, comparing various methods. With optimised conditions, we were able to obtain 4±2% (ndc) yield of [(11)C]Raclopride (100 GBq [(11)C]CO2, n = 42) in 25 min. The radiochemical purity was >95% with specific activities of 135±41 MBq/nmol at end of synthesis. © 2014 Bentham Science Publishersen_AU
dc.identifier.citationPerkins, G., Sheth, R., Greguric, I., & Pascali, G. (2014). Optimisation of [11C] raclopride production using a synthra gpextent system. Current Radiopharmaceuticals, 7(2), 100-106. doi:10.2174/1874471007666141021111635en_AU
dc.identifier.govdoc8848en_AU
dc.identifier.issn1874-4710en_AU
dc.identifier.issue2en_AU
dc.identifier.journaltitleCurrent Radiopharmaceuticalsen_AU
dc.identifier.pagination100-106en_AU
dc.identifier.urihttps://doi.org/10.2174/1874471007666141021111635en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/9290en_AU
dc.identifier.volume7en_AU
dc.language.isoenen_AU
dc.publisherBentham Science Publishersen_AU
dc.subjectDopamineen_AU
dc.subjectReceptorsen_AU
dc.subjectClinical trialsen_AU
dc.subjectTestingen_AU
dc.subjectSynthesisen_AU
dc.subjectImpuritiesen_AU
dc.titleOptimisation of [11C]raclopride production using a synthra GPextent systemen_AU
dc.typeJournal Articleen_AU
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