Ascertaining the suitability of aryl sulfonyl fluorides for [18F]radiochemistry applications: a systematic investigation using microfluidics

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dc.contributor.authorMatesic, Len_AU
dc.contributor.authorWyatt, NAen_AU
dc.contributor.authorFraser, BHen_AU
dc.contributor.authorRoberts, MPen_AU
dc.contributor.authorPham, TQen_AU
dc.contributor.authorGreguric, Ien_AU
dc.date.accessioned2018-09-17T02:34:04Zen_AU
dc.date.available2018-09-17T02:34:04Zen_AU
dc.date.issued2013-10-18en_AU
dc.date.statistics2018-09-16en_AU
dc.description.abstractOptimization of [18F]radiolabeling conditions and subsequent stability analysis in mobile phase, PBS buffer, and rat serum of 12 aryl sulfonyl chloride precursors with various substituents (electron-withdrawing groups, electron-donating groups, increased steric bulk, heterocyclic) were performed using an Advion NanoTek Microfluidic Synthesis System. A comparison of radiochemical yields and reaction times for a microfluidics device versus a conventional reaction vessel is reported. [18F]Radiolabeling of sulfonyl chlorides in the presence of competing nucleophiles, H-bond donors, and water was also assessed and demonstrated the versatility and potential utility of [18F]sulfonyl fluorides as synthons for indirect radiolabeling. © 2013 American Chemical Societyen_AU
dc.identifier.citationMatesic, L., Wyatt, N. A., Fraser, B. H., Roberts, M. P., Pham, T. Q., & Greguric, I. (2013). Ascertaining the suitability of aryl sulfonyl fluorides for [18F] radiochemistry applications: a systematic investigation using microfluidics. The Journal of Organic Chemistry, 78(22), 11262-11270. doi:10.1021/jo401759zen_AU
dc.identifier.govdoc8808en_AU
dc.identifier.issn1520-6904en_AU
dc.identifier.issue22en_AU
dc.identifier.journaltitleThe Journal of Organic Chemistryen_AU
dc.identifier.pagination11262-11270en_AU
dc.identifier.urihttps://doi.org/10.1021/jo401759zen_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/9007en_AU
dc.identifier.volume78en_AU
dc.language.isoenen_AU
dc.publisherAmerican Chemical Societyen_AU
dc.subjectPositron computed tomographyen_AU
dc.subjectRadiopharmaceuticalsen_AU
dc.subjectLabelled compoundsen_AU
dc.subjectFluidsen_AU
dc.subjectRadiochemistryen_AU
dc.subjectMoleculesen_AU
dc.titleAscertaining the suitability of aryl sulfonyl fluorides for [18F]radiochemistry applications: a systematic investigation using microfluidicsen_AU
dc.typeJournal Articleen_AU
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