Characterisation of partial volume effect and region-based correction in small animal positron emission tomography (PET) of the rat brain

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dc.contributor.authorLehnert, Wen_AU
dc.contributor.authorGrégoire, MCen_AU
dc.contributor.authorReilhac, Aen_AU
dc.contributor.authorMeikle, SRen_AU
dc.date.accessioned2018-09-17T02:02:40Zen_AU
dc.date.available2018-09-17T02:02:40Zen_AU
dc.date.issued2012-05-01en_AU
dc.date.statistics2108-09-16en_AU
dc.description.abstractAccurate quantification of PET imaging data is required for a useful interpretation of the measured radioactive tracer concentrations. The partial volume effect (PVE) describes signal dilution and mixing due to spatial resolution and sampling limitations, which introduces bias in quantitative results. In the present study we investigated the magnitude of PVE for volumes of interest (VOIs) in the rat brain and the effect of positron range. In simulated 11C-raclopride studies we examined the influence of PVE on time activity curves in striatal and cerebellar VOIs and binding potential estimation. The performance of partial volume correction (PVC) was studied using the region-based geometric transfer matrix (GTM) method including the question of whether a spatially variant point spread function (PSF) is necessary for PVC of a rat brain close to the centre of the field of view. Furthermore, we determined the effect of spillover from activity outside the brain. The results confirmed that PVE is significant in rat brain PET and showed that positron range is an important factor that needs to be included in the PSF. There was considerable bias in time activity curves for the simulated 11C-raclopride studies and significant underestimation of binding potential even for very small centred VOIs. Good activity recovery was achieved with the GTM PVC using a spatially invariant simulated PSF when no activity was present outside the brain. PVC using a simple Gaussian fit point spread function was not sufficiently accurate. Spillover from regions outside the brain had a significant impact on measured activity concentrations and reduced the accuracy of PVC with the GTM method using rat brain regions alone, except for the smallest VOI size but at the cost of increased noise. Voxel-based partial volume correction methods which inherently compensate for spillover from outside the brain might be a more suitable choice. © 2012 Elsevier Inc.en_AU
dc.identifier.citationLehnert, W., Grégoire M. C., Reilhac, A., & Meikle, S. R. (2012). Characterisation of partial volume effect and region-based correction in small animal positron emission tomography (PET) of the rat brain. NeuroImage, 60(4), 2144-2157. doi:10.1016/j.neuroimage.2012.02.032en_AU
dc.identifier.govdoc8802en_AU
dc.identifier.issn1053-8119en_AU
dc.identifier.issue4en_AU
dc.identifier.journaltitleNeuroImageen_AU
dc.identifier.pagination2144-2157en_AU
dc.identifier.urihttps://doi.org/10.1016/j.neuroimage.2012.02.032en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/9005en_AU
dc.identifier.volume60en_AU
dc.language.isoenen_AU
dc.publisherElsevier Incen_AU
dc.subjectPositron computed tomographyen_AU
dc.subjectRatsen_AU
dc.subjectBrainen_AU
dc.subjectImagesen_AU
dc.subjectSimulationen_AU
dc.subjectCarbon 11en_AU
dc.titleCharacterisation of partial volume effect and region-based correction in small animal positron emission tomography (PET) of the rat brainen_AU
dc.typeJournal Articleen_AU
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