Protein-ligand and membrane-ligand interactions in pharmacology: the case of the translocator protein (TSPO)

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dc.contributor.authorHatty, CRen_AU
dc.contributor.authorBanati, RBen_AU
dc.date.accessioned2020-03-16T23:46:56Zen_AU
dc.date.available2020-03-16T23:46:56Zen_AU
dc.date.issued2015-10-01en_AU
dc.date.statistics2020-03-11en_AU
dc.description.abstractThe targets of many small molecule drugs are membrane proteins, and traditionally the focus of pharmacology is on the interaction between such receptors and their small molecule drug ligands. However, the lipid membranes of cells and organelles are increasingly appreciated as diverse and dynamic structures that also specifically interact with small molecule drugs and peptides, causing profound changes in the properties of these membranes, and modulating the function of the membrane and the proteins within it. Drug-membrane interactions are likely to have a role in both the therapeutic and toxic activity of a variety of compounds, and their role in the overall pharmacological effect of a drug needs to be understood more clearly. This is the case for the 18 kDa translocator protein (TSPO) and its ligands, where functions that were established based on pharmacological studies are being called into question. Re-examining the putative functions of the TSPO and the effects of its ligands reveals a need to consider in more detail the interplay between protein-ligand and membrane-ligand interactions, and the modulatory relationship between TSPO and the lipid membrane. © 2015 Elsevier Ltd.en_AU
dc.identifier.citationHatty, C. R., & Banati, R. B. (2015). Protein-ligand and membrane-ligand interactions in pharmacology: the case of the translocator protein (TSPO). Pharmacological Research, 100, 58-63. doi:10.1016/j.phrs.2015.07.029en_AU
dc.identifier.govdoc8768en_AU
dc.identifier.issn1043-6618en_AU
dc.identifier.journaltitlePharmacological Researchen_AU
dc.identifier.pagination58-63en_AU
dc.identifier.urihttps://doi.org/10.1016/j.phrs.2015.07.029en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/9161en_AU
dc.identifier.volume100en_AU
dc.language.isoenen_AU
dc.publisherElsevier B.V.en_AU
dc.subjectDrugsen_AU
dc.subjectPharmacologyen_AU
dc.subjectReceptorsen_AU
dc.subjectLigandsen_AU
dc.subjectPeptidesen_AU
dc.subjectMembranesen_AU
dc.subjectCholesterolen_AU
dc.titleProtein-ligand and membrane-ligand interactions in pharmacology: the case of the translocator protein (TSPO)en_AU
dc.typeJournal Articleen_AU
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