Radiochemistry on chip: towards dose-on-demand synthesis of PET radiopharmaceuticals

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dc.contributor.authorArima, Ven_AU
dc.contributor.authorPascali, Gen_AU
dc.contributor.authorLade, Oen_AU
dc.contributor.authorKretschmer, HRen_AU
dc.contributor.authorBernsdorf, Ien_AU
dc.contributor.authorHammond, Ven_AU
dc.contributor.authorWatts, Pen_AU
dc.contributor.authorDe Leonardis, Fen_AU
dc.contributor.authorTarn, MDen_AU
dc.contributor.authorPamme, Nen_AU
dc.contributor.authorCvetkovic, BJen_AU
dc.contributor.authorDitrrich, PSen_AU
dc.contributor.authorVasovic, Nen_AU
dc.contributor.authorDuane, Ren_AU
dc.contributor.authorJaksic, Aen_AU
dc.contributor.authorZacheo, Aen_AU
dc.contributor.authorZizzari, Aen_AU
dc.contributor.authorMarra, Len_AU
dc.contributor.authorPerrone, Een_AU
dc.contributor.authorSalvadori, PAen_AU
dc.contributor.authorRinaldi, Ren_AU
dc.date.accessioned2020-03-11T23:29:05Zen_AU
dc.date.available2020-03-11T23:29:05Zen_AU
dc.date.issued2013-03-25en_AU
dc.date.statistics2020-03-11en_AU
dc.description.abstractAbstractWe have developed an integrated microfluidic platform for producing 2-[18F]-fluoro-2-deoxy-D-glucose (18F-FDG) in continuous flow from a single bolus of radioactive isotope solution, with constant product yields achieved throughout the operation that were comparable to those reported for commercially available vessel-based synthesisers (40–80%). The system would allow researchers to obtain radiopharmaceuticals in a dose-on-demand setting within a few minutes. The flexible architecture of the platform, based on a modular design, can potentially be applied to the synthesis of other radiotracers that require a two-step synthetic approach, and may be adaptable to more complex synthetic routes by implementing additional modules. It can therefore be employed for standard synthesis protocols as well as for research and development of new radiopharmaceuticals. © 2013 The Royal Society of Chemistryen_AU
dc.identifier.citationArima, V., Pascali, G., Lade, O., Kretschmer, H. R., Bernsdorf, I., Hammond, V.,Watts, P., De Leonardis, F., Tarn, M. D., Pamme, N., Cvetkovic, B.J., Dittrich, P. S., Vasovic, N., Duane., R., Jaksic, A., Zacheo, A., Zizzari, A., Marra, L., Perrone, E., Salvadori, P. A., & Rinaldi, R. (2013). Radiochemistry on chip: towards dose-on-demand synthesis of PET radiopharmaceuticals. Lab on a Chip, 13(12), 2328-2336. doi:10.1039/C3LC00055Aen_AU
dc.identifier.govdoc8664en_AU
dc.identifier.issn1473-0197en_AU
dc.identifier.issue12en_AU
dc.identifier.journaltitleLab on a Chipen_AU
dc.identifier.pagination2328-2336en_AU
dc.identifier.urihttp://doi.org/10.1039/C3LC00055Aen_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/9138en_AU
dc.identifier.volume13en_AU
dc.language.isoenen_AU
dc.publisherThe Royal Society of Chemistryen_AU
dc.subjectPositron computed tomographyen_AU
dc.subjectRadiopharmaceuticalsen_AU
dc.subjectSynthesisen_AU
dc.subjectFluorodeoxyglucoseen_AU
dc.subjectGlucoseen_AU
dc.subjectLabelled compoundsen_AU
dc.titleRadiochemistry on chip: towards dose-on-demand synthesis of PET radiopharmaceuticalsen_AU
dc.typeJournal Articleen_AU
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