Influence of metal ions on the Ga-68-labeling of dotatate

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dc.contributor.authorOehlke, Een_AU
dc.contributor.authorLe, VSen_AU
dc.contributor.authorLengkeek, NAen_AU
dc.contributor.authorPellegrini, PAen_AU
dc.contributor.authorJackson, TWen_AU
dc.contributor.authorGreguric, Ien_AU
dc.contributor.authorWeiner, Ren_AU
dc.date.accessioned2015-10-19T23:56:05Zen_AU
dc.date.available2015-10-19T23:56:05Zen_AU
dc.date.issued2013-12-01en_AU
dc.date.statistics2015-10-15en_AU
dc.description.abstractThe influence of metal cations (Fe3+, Fe2+, In3+, Cu2+, Ca2+, Al3+, Co2+, Lu3+, Ni2+, Pb2+, Ti4+, Y3+, Yb3+, Zn2+, and Zr4+) on the radiolabeling yield of [68Ga(DOTATATE)] was evaluated. Our most important observation was that, within our experimental limit, the metal ion/ligand ratio plays a critical role on the influence of most metal ions. More in-depth studies, with Cu2+ and Fe3+, revealed that reaction temperature and concentration changes have little effect, but speciation changes with pH are crucial. Furthermore, we found that [68Ga(DOTATATE)] is stable in the presence of high concentrations of Fe3+, Zn2+ and Pb2+, but transmetalates with Cu2+ at 95 °C. © 2013, Elsevier Ltd.en_AU
dc.identifier.citationOehlke, E., Le, V. S., Lengkeek, N., Pellegrini, P., Jackson, T., Greguric, I., & Weiner, R. (2013). Influence of metal ions on the Ga-68-labeling of DOTATATE. Applied Radiation and Isotopes, 82, 232-238. doi:10.1016/j.apradiso.2013.08.010en_AU
dc.identifier.govdoc6185en_AU
dc.identifier.issn0969-8043en_AU
dc.identifier.journaltitleApplied Radiation and Isotopesen_AU
dc.identifier.pagination232-238en_AU
dc.identifier.urihttp://dx.doi.org/10.1016/j.apradiso.2013.08.010en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/6337en_AU
dc.identifier.volume82en_AU
dc.language.isoenen_AU
dc.publisherElsevieren_AU
dc.subjectCationsen_AU
dc.subjectStabilityen_AU
dc.subjectMetalsen_AU
dc.subjectIonsen_AU
dc.subjectLigandsen_AU
dc.subjectColloidsen_AU
dc.titleInfluence of metal ions on the Ga-68-labeling of dotatateen_AU
dc.typeJournal Articleen_AU
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